Strawberry Hemangioma in Preterm Infants

Amir, Jacob; Metzker, Aryeh; Krikler, R.; Reisner, Salomon H.

doi:10.1111/j.1525-1470.1986.tb00535.x

Cited by 261 publications

(133 citation statements)

References 9 publications

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“…No other tissue jointly expresses these markers. A placental origin would explain the 3-fold higher incidence of hemangiomas in infants born after transcervical chorionic villus sampling (21) and the association between hemangioma and prematurity (22) because prematurity may result from placental complications (13).…”

mentioning

confidence: 99%

Evidence by molecular profiling for a placental origin of infantile hemangioma

Barnes

Huang

Kaipainen

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

176

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The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559 -570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-␤ hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.angiogenesis ͉ endothelium ͉ microarray ͉ gene array

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mentioning

confidence: 99%

Evidence by molecular profiling for a placental origin of infantile hemangioma

Barnes

Huang

Kaipainen

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

176

View full text Add to dashboard Cite

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“…To be so small to be noticed at birth, late recognition by family, and Parallel to the fact that only the hemangiomas adjacent to the lips do not usually regress because of being fed directly from the labial artery, lip hemangiomas in 2 cases of our series did not show regression 13 .…”

Section: Discussionmentioning

confidence: 78%

“…Rate of hemangiomas in terms ranges from 1 to 4%, but this rate increase to 22% in preterms 13 . Prematurity rate was 6.1% in this study.…”

Section: Discussionmentioning

confidence: 99%

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Clinical features and treatment results in children with hemangioma

2017

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“…1 It is more prevalent in female infants and in preterm infants, particularly those weighing less than 1500 g. [1][2][3] The course is characterized by rapid proliferation in the first year of life, followed by a slow, gradual involution over the next 5-7 years. 4,5 The exact aetiology is not well understood, and may involve aberrant vascular dysgenesis, 6 hormonal or immune-mediated processes, infections, and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

Intralesional and sub-Tenon's infusion of corticosteroids for treatment of refractory periorbital and orbital capillary haemangioma

Friling

Axer‐Siegel

Ben‐Amitai

et al. 2008

Eye

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Purpose To evaluate the effect of combined intralesional and sub-Tenon's administration of corticosteroids for the treatment of refractory periocular and orbital capillary haemangioma in a retrospective, noncomparative study. Methods Seven infants with resistant periorbital and orbital capillary haemangioma who attended our tertiary centre from 2000 to 2005 were treated with an intralesional injection of a mixture of betamethasone 6 mg/cc and triamcinolone 10 mg/cc, by body weight, together with sub-Tenon's infusion of betamethasone 6 mg/cc and triamcinolone 40 mg/cc of a volume of 1 cc, close to the orbital lesion, in the same session. Visual axis, proptosis, pre-and post-treatment changes in four refractive parameters, and parental satisfaction were evaluated. Results None of the babies had proptosis or visual axis obstruction after treatment. Mean spherical power decreased by 22.7% (P ¼ 0.06). Mean spherical equivalent decreased in 34%, but the difference was not statistically significant (P ¼ 0.09). No early or late ocular side effects were observed. Mean intraocular pressure results were normal before and immediately after treatment, and during the follow-up period. Parental satisfaction score during follow-up was 9/10. Mean time to improvement was 96.43 ± 58.3 days. Conclusions Combined local corticosteroid administration by posterior sub-Tenon's infusion and intralesional injection in babies with extensive capillary haemangioma is associated with a satisfactory anatomical and functional outcome and there were no ophthalmic side effects.

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Strawberry Hemangioma in Preterm Infants

Cited by 261 publications

References 9 publications

Evidence by molecular profiling for a placental origin of infantile hemangioma

Evidence by molecular profiling for a placental origin of infantile hemangioma

Clinical features and treatment results in children with hemangioma

Intralesional and sub-Tenon's infusion of corticosteroids for treatment of refractory periorbital and orbital capillary haemangioma

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