Stratigraphy and mineralogy of Unit H, Nagoorin South oil shale deposit

Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.

“…While there was evidence that LIF can be produced by glial cells in culture (16,34), recent Northern blot (35) and in situ analysis shows that Schwann cells can dramatically up-regulate LIF expression in response to peripheral nerve section (36,37). In addition, recombinant LIF can duplicate the effects of nerve injury in the induction of particular neuropeptides in sympathetic neurons (6,37,38). In striking confirmation of this model, when sympathetic nerves are cut in LIFmice, the neuropeptide induction is greatly diminished compared to the neuronal response in wild-type mice (19).…”

“…Several of these proteins can, for instance, induce the same set of acute-phase response proteins in liver, support the self renewal of cultured embryonic stem cells, inhibit lipogenesis, and enhance the survival of cultured motor neurons (see ref. 6). Despite their limited homology, the neuropoietic cytokines are predicted to share a four antiparallel helix bundle secondary structure (7,8), a prediction that is borne out by the recent structure determination of CNTF (N. McDonald, personal communication).…”