Stratified Temperature-Responsive Multilayer Hydrogels of Poly(<i>N</i>-vinylpyrrolidone) and Poly(<i>N</i>-vinylcaprolactam): Effect of Hydrogel Architecture on Properties

Higgins, William; Kozlovskaya, Veronika; Alford, Aaron; Ankner, John F.; Kharlampieva, Eugenia

doi:10.1021/acs.macromol.6b00964

Cited by 28 publications

(47 citation statements)

References 77 publications

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“…We have also developed multistrata multilayer hydrogels and explored the effect of internal layering on the volume changes of PVCL within non-ionic double-stack hydrogels, made from PVCL and temperature unresponsive hydrophilic and biocompatible PVPON (Figure 3). 58 A PVPON multilayer hydrogel was assembled as either a top or bottom stack of the double-stack (PVCL) n (PVPON) m hydrogel. This multilayer hydrogel exhibits an architectural hierarchy where the hydrogel coating is made of two multilayer stacks with each of them being assembled from either PVPON or PVCL chains.…”

Section: Acs Applied Polymer Materialsmentioning

confidence: 99%

“…The amount of hydrophilic PVPON layers assembled above the PVCL stack could be also used to increase the wettability of (PVCL)n hydrogel surface. 58 Thus, the use of the ultrathin multistrata hydrogel films assembled through multilayer deposition of temperaturesensitive polymers can be used to finely control the thickness and wettability of nanoscale coatings using temperature which can be relevant for applications in cell and tissue engineering.…”

Section: Acs Applied Polymer Materialsmentioning

confidence: 99%

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Self-Assemblies of Thermoresponsive Poly(N-vinylcaprolactam) Polymers for Applications in Biomedical Field

Kozlovskaya

Kharlampieva

2019

ACS Appl. Polym. Mater.

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Poly(N-vinylcaprolactam) (PVCL) is a temperature-responsive polymer with a lower critical solution temperature (LCST) in the physiological range. PVCL’s unique features include thermosensitivity controlled by concentration and molecular weight, as well as excellent biocompatibility and nontoxicity. In comparison to other thermosensitive polymer structures, PVCL-based materials have been much less investigated. This Spotlight focuses on PVCL materials whose nanostructure can be precisely controlled during self-assembly in aqueous solutions. Recent developments in synthesis of amphiphilic PVCL-containing polymers including random, diblock, and triblock copolymers are reviewed. We overview templated and solution-based self-assembly approaches developed in our group to present thermosensitive assemblies ranging from thin coatings and hydrogels to micelles, polymersomes, nanogels, and capsules. The fundamental issues related to their structure–property relationships for temperature, pH, and enzymatic sensitivity are discussed, and their impact on applications in the biomedical field are emphasized. Finally, we outline the prospects of PVCL constructs to be developed in advanced materials with on-demand properties.

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Section: Acs Applied Polymer Materialsmentioning

confidence: 99%

Section: Acs Applied Polymer Materialsmentioning

confidence: 99%

Self-Assemblies of Thermoresponsive Poly(N-vinylcaprolactam) Polymers for Applications in Biomedical Field

Kozlovskaya

Kharlampieva

2019

ACS Appl. Polym. Mater.

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“…Such multilayers have been employed as template for thin-layer hydrogels, where one of the layers was crosslinked after deposition of a thin film and removal of the other polymer layer, as shown with the systems PVP/PMAA, [232,233] poly(vinylcaprolactam)/PMAA [234,235] or both. [236] The combination of PVP and PMAA with subsequent crosslinking was later also employed to form capsules with thin crosslinked polyelectrolyte complex shell. [237] Trau and coworkers used an agarose microbead as template for coating with poly(allylamine) (PA) and poly(styrene sulfonic acid) via layer-bylayer process.…”

Section: Multilayer Hydrogelsmentioning

confidence: 99%

Multicompartment Hydrogels

Schmidt

2022

Macromol. Rapid Commun.

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Hydrogels belong to the most promising materials in polymer and materials science at the moment. As they feature soft and tissue-like character as well as high water-content, a broad range of applications are addressed with hydrogels, e.g., tissue engineering and wound dressings but also soft robotics, drug delivery, actuators, and catalysis. Ways to tailor hydrogel properties are crosslinking mechanisms, hydrogel shape, and reinforcement, but new features can be introduced by variation of hydrogel composition as well, e.g., via monomer choice, functionalization or compartmentalization. In particular, multicompartment hydrogels drive progress toward complex and highly functional soft materials. In the present review the latest developments in multicompartment hydrogels are highlighted with a focus on three types of compartments; micellar/vesicular, droplets, and multilayers including various subcategories. Furthermore, several morphologies of compartmentalized hydrogels and applications of multicompartment hydrogels will be discussed as well. Finally, an outlook toward future developments of the field will be given. The further development of multicompartment hydrogels is highly relevant for a broad range of applications and will have a significant impact on biomedicine and organic devices.

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“…The fabrication of various architectures for SAH is demonstrated in Figure 9a and b According to the IUPAC definitions [46], semi-IPN networks are composited of one linear polymer entrapped within the network of another polymer, while IPN networks comprise more than one polymer network structures interlaced on a molecular scale. Figure 9c is an image of a multilayer hydrogel (MLH) [47] in which single networks are stacked one onto the other, interpenetrating network films with the mixture of two networks in the same layer. Figure 9f is an image of hydrogel fibers [48][49][50].…”

Section: Design Of the Polymerization Reaction According To Appropriamentioning

confidence: 99%

Superabsorbent

El-Sayyad¹

2018

Hydrogels

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Superabsorbent hydrogel (SAH) is a cross-linked polyelectrolyte polymer that has the capability to absorb a lot of water by keeping it in a three-dimensional (3D) structure. The network's structure of SAH has the high elasticity that gives the ability of pores to expand in an aqueous media into up to 150-1500 times their own size in a dry state. The size of pores is the major factor that controls the swelling degree of the hydrogel. In contrast, the swelling degree is related to cross-linked density and the number of polarizable functional groups that immobilize on the polymer backbone. The hydrogels could be made by radical-initiated polymerization of hydrophilic monomers, and/or linear polymers dissolve in an aqueous solution. Free radical polymerization of the hydrogel can be done physically or chemically. Advantages and disadvantages of each method will be elaborated in this chapter. The advances in radiation cross-linking methods for the hydrogel preparation are particularly addressed besides other different techniques, e.g., (freezing/ thawing and chemical initiation). This chapter will review the preparation methods of superabsorbent hydrogels from synthetic and natural hydrophilic polymers with other new phases such as wax, gum, and rubber. Methods to characterize these hydrogels and their proposed applications (internal curing agent for cement, agricultural proposal, biomedical proposal, and environmental proposal) are also reviewed.

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Stratified Temperature-Responsive Multilayer Hydrogels of Poly(N-vinylpyrrolidone) and Poly(N-vinylcaprolactam): Effect of Hydrogel Architecture on Properties

Cited by 28 publications

References 77 publications

Self-Assemblies of Thermoresponsive Poly(N-vinylcaprolactam) Polymers for Applications in Biomedical Field

Self-Assemblies of Thermoresponsive Poly(N-vinylcaprolactam) Polymers for Applications in Biomedical Field

Multicompartment Hydrogels

Superabsorbent

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