2018
DOI: 10.1111/rssc.12284
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Stratified Space–Time Infectious Disease Modelling, with an Application to Hand, Foot and Mouth Disease in China

Abstract: We extend an interesting class of space–time models for infectious disease data proposed by Held and co‐workers, to analyse data on hand, foot and mouth disease, collected in the central north region of China over 2009–2011. We provide a careful derivation of the model and extend the model class in two directions. First, we model the disease transmission between age–gender strata, in addition to space and time. Second, we use our model for inference on effective local reproductive numbers. For the hand, foot a… Show more

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Cited by 23 publications
(35 citation statements)
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“…To model the spread of COVID-19 in Africa, we employ a data-driven endemic-epidemic model ( 33 ) to 1) visualize the burden of cases including the proportion of cases arising from sources local within-country and external between-country, 2) describe the factors which most correlate with spread, and 3) enable short-term forecasting of new cases. This modeling framework has been used previously to fit space-time dynamics of COVID-19 in Italy ( 34 ), Germany ( 35 ) and the United Kingdom ( 36 ) and to analyze other infectious diseases ( 37 ). The model is divided into three main parts: two epidemic components that capture sources of infections coming from within the country and from neighboring areas, and an endemic component that includes all contributions to the reported number of cases that are not taken into account by the epidemic part.…”
Section: Introductionmentioning
confidence: 99%
“…To model the spread of COVID-19 in Africa, we employ a data-driven endemic-epidemic model ( 33 ) to 1) visualize the burden of cases including the proportion of cases arising from sources local within-country and external between-country, 2) describe the factors which most correlate with spread, and 3) enable short-term forecasting of new cases. This modeling framework has been used previously to fit space-time dynamics of COVID-19 in Italy ( 34 ), Germany ( 35 ) and the United Kingdom ( 36 ) and to analyze other infectious diseases ( 37 ). The model is divided into three main parts: two epidemic components that capture sources of infections coming from within the country and from neighboring areas, and an endemic component that includes all contributions to the reported number of cases that are not taken into account by the epidemic part.…”
Section: Introductionmentioning
confidence: 99%
“…To circumvent this, more sophisticated algorithms seem to be needed. Secondly, prior choice is challenging in EE models (Bauer and Wakefield, 2018). Advantages, however, are that the uncertainty about the reporting probability π could be included more easily and that the hidden process {X t } could be reconstructed.…”
Section: Discussionmentioning
confidence: 99%
“…This model class is of particular interest in epidemiological applications as it can be derived from a mechanistic model of disease transmission (Wakefield et al, 2019) and serve to estimate effective reproductive numbers. The EE class has been used for this purpose by Wang et al (2011) and Bauer and Wakefield (2018), but without accounting for underreporting of surveillance data.…”
Section: Introductionmentioning
confidence: 99%
“…The parameters ν kt , λ kt , and φ kt are constrained to be non-negative and can be modeled by allowing for log-linear predictors in all three components, as sine-cosine terms to account for seasonality [42], long-term temporal trends, or/and covariates [43,44].…”
Section: Endemic-epidemic Models R Package Surveillance [26]mentioning
confidence: 99%