Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

Nisar, Safiya; Pandit, Ashiq Hussain; Wang, Lifang; Rattan, Sunita

doi:10.1039/c9ra10333c

Cited by 43 publications

(19 citation statements)

References 66 publications

(64 reference statements)

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“…Therefore, to prevent the oxidation of magnetic nanoparticles, a new approach should be considered, such as modifying the nanoparticles' surface with polymer groups or using a mold to prevent the nanoparticles from oxidizing for a specic structure, which can be useful approaches. 32,33 In the recent past, some green plant polymers ,34 such as nanober cellulose, lignin, and hemicellulose, polylactic acid (PLA), 35,36 chitin 37,38 and chitosan, 39,40 were considered. Among the various materials used as a mold to prevent oxidation of magnetic nanoparticles, cellulose nanober can be mentioned because of its many capabilities, including low cost, easy access, biodegradability, low density, excellent mechanical properties, and high level.…”

Section: Introductionmentioning

confidence: 99%

Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene

2021

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Section: Introductionmentioning

confidence: 99%

Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene

2021

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“…In addition, the time required to reach swelling equilibrium is also extremely important. This characteristic is pivotal for several precise applications, such as drug delivery and the design of scaffolds for tissue regeneration and repair [ 42 , 43 , 44 ]. Our study established not only the amount of water absorbed by the two type of systems but also their swelling profile, as in the computed parameters, i.e., equilibrium water content, (EWC, %) and swelling content (SC, g/g), providing important insights regarding the time required for the synthesized systems to reach the maximum hydration and also the maximum amount of aqueous media they are able to uptake.…”

Section: Resultsmentioning

confidence: 99%

Double-Cross-Linked Networks Based on Methacryloyl Mucin

et al. 2021

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Mucin is a glycoprotein with proven potential in the biomaterials field, but its use is still underexploited for such applications. The present work aims to produce a synthesis of methacryloyl mucin single-network (SN) hydrogels and their double-cross-linked-network (DCN) counterparts. Following the synthesis of the mucin methacryloyl derivative, various SN hydrogels are prepared through the photopolymerization of methacrylate bonds, using reaction media with different pH values. The SN hydrogels are converted into DCN systems via supplementary cross-linking in tannic acid aqueous solution. The chemical modification of mucin is described, and the obtained product is characterized; the structural modification of mucin is assessed through FTIR spectroscopy, and the circular dichroism and the isoelectric point of methacryloyl mucin is evaluated. The affinity for aqueous media of both SN and DCN hydrogels is estimated, and the mechanical properties of the systems are assessed, both at macroscale through uniaxial compression and rheology tests and also at microscale through nanoindentation tests.

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“…For HACGD, the C-Cl stretching vibration strong absorption peak showed at 769 cm −1 . The further structural data of those compounds were interpreted by 1 H NMR [38][39][40].…”

Section: Ft-ir Analysismentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases

Cui

Ji²,

et al. 2022

Marine Drugs

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N-2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC), a cationic quaternary ammonium salt polymer exhibiting good solubility in water, is widely used because of its low toxicity and good biocompatibility. Herein, through ion exchange reaction, we prepared N-2-hydroxypropyltrimethyl ammonium chitosan derivatives bearing amino acid Schiff bases with good biological activities. The accuracy of the structures was verified by FT-IR and 1H NMR. The antibacterial activity, antifungal activity, and scavenging ability of DPPH radical and superoxide radical of HACC derivatives were significantly improved compared with that of HACC. In particular, HACGM (HACC-potassium 2-((2-hydroxy-3-methoxybenzylidene)amino)acetate) and HACGB (HACC-potassium 2-((5-bromo-2-hydroxybenzylidene)amino)acetate) showed good inhibitory effect on bacteria and fungi, including Staphylococcus aureus, Escherichia coli, Botrytis cinerea, and Fusarium oxysporum f. sp. cubense. The inhibition rate of HACGB on Staphylococcus aureus and Escherichia coli could reach 100% at the concentration of 0.1 mg/mL, and the inhibition rate of HACGM and HACGB on Botrytis cinerea and Fusarium oxysporum f. sp. cubense could also reach 100% at the concentration of 0.5 mg/mL. Improving antimicrobial and antioxidant activities of HACC could provide ideas and experiences for the development and utilization of chitosan derivatives.

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Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

Abstract: We report the synthesis of a novel photocleavable crosslinker and its joining with amine-based polysachharides, viz. chitosan, resulting in the formation of a dual stimuli-responsive hydrogel having UV- and pH-responsive sites.

Cited by 43 publications

References 66 publications

Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene

Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene

Double-Cross-Linked Networks Based on Methacryloyl Mucin

Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases

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