1992
DOI: 10.1002/tcm.1770120205
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Strategy of research for cancer—chemoprevention

Abstract: It has been reported that environmental chemicals are important factors in terms of both development and prevention of human cancer. For the latter, detection of early stages is an essential first step followed by clinical trials for surveying populations at risk. Thus a great deal of attention has been focused on these areas. However, investigations of possibilities for active prevention of cancer development itself form another major project. Chemoprevention of carcinogenesis, which means prevention of carci… Show more

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Cited by 22 publications
(4 citation statements)
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“…However, foci of altered hepatocytes, considered to be preneoplastic lesions, are often present in aged rats [11][12][13][14], so chemopreventive agents might be expected to reduce their size or numbers. With regard to the human risk of hepatocarcinogenicity in individuals consuming phenolic compounds for long periods, no adequate data have been reported [15,16].…”
Section: Introductionmentioning
confidence: 96%
“…However, foci of altered hepatocytes, considered to be preneoplastic lesions, are often present in aged rats [11][12][13][14], so chemopreventive agents might be expected to reduce their size or numbers. With regard to the human risk of hepatocarcinogenicity in individuals consuming phenolic compounds for long periods, no adequate data have been reported [15,16].…”
Section: Introductionmentioning
confidence: 96%
“…The ingestion of fruits and vegetables may lead to a protective effect in the occurrence of human cancer, due not only to flavonoids but also due to other phytochemicals such as chlorophyllin, indoles, isothiocyanates, sterols, phenols, protease inhibitors, and vitamins present in plants (Ito and Imaida, 1992). In terms of their potential mediation of cancer chemoprevention, flavonoids have been shown to interact in the genesis of cancer in all of its various stages of initiation, promotion, and progression (Ito and Imaida, 1992).…”
Section: Biological Activitymentioning
confidence: 99%
“…The ingestion of fruits and vegetables may lead to a protective effect in the occurrence of human cancer, due not only to flavonoids but also due to other phytochemicals such as chlorophyllin, indoles, isothiocyanates, sterols, phenols, protease inhibitors, and vitamins present in plants (Ito and Imaida, 1992). In terms of their potential mediation of cancer chemoprevention, flavonoids have been shown to interact in the genesis of cancer in all of its various stages of initiation, promotion, and progression (Ito and Imaida, 1992). For example, these compounds have been shown to block the promotion stage of carcinogenesis, and inhibit ornithine decarboxylase (ODC) synthesis, alter hormonal balance and cause the reduction of free radicals (Fujiki et al, 1986;Hatano et al, 1988;Fujita et al, 1989;Huang et al, 1992).…”
Section: Biological Activitymentioning
confidence: 99%
“…A multiorgan 28-weeklong system based on the mechanistic initiation–promotion concept of chemical carcinogenesis was proposed by a research group led by Nobuyuki Ito at the Nagoya City University Medical School, Japan, as an alternative/complementary approach to the conventional long-term bioassay system (Ito et al 1996, 1988; Shirai, Hirose, and Ito 1999; Ito and Imaida 1992; Ito et al 1998). It consists of sequential treatment of rats with five genotoxic carcinogens to establish multiorgan initiation of carcinogenesis followed by dietary exposure to a test substance in order to evaluate its promoting potential.…”
mentioning
confidence: 99%