Strategies toward development of biodegradable hydrogels for biomedical applications

Mallick, Sarada Prasanna; Suman, Dheerendra Kumar; Singh, B. N.; Srivastava, Pradeep; Siddiqui, Nadeem; Yella, Venkata Rajesh; Madhual, Abhimanyu; Vemuri, Praveen Kumar

doi:10.1080/25740881.2020.1719135

Cited by 15 publications

(12 citation statements)

References 78 publications

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“…Upon reaching the desired final temperature, i.e., 298 K, the system was equilibrated for another 500 ps in the NPT ensemble and then for another 500 ps in the NVT ensemble. This procedure leads to a final density of 1.26 g/cm 3 , which is in good agreement with the experimental value of 1.35 g/cm 3 [83].…”

Section: Preparation Of Molecular Models Of Hydrogel Structuressupporting

confidence: 87%

“…Biodegradable hydrogels are a specific group of functional materials that are gaining more and more applicability in various fields. The most important ones include medicine [1][2][3], tissue engineering [4][5][6], pharmaceutics [7][8][9], diagnostics [10][11][12], the food industry [13][14][15], cosmetics [16], and gardening and agriculture [17][18][19][20]. Despite their biodegradability, the greatest merits of such hydrogels are their biocompatibility, semipermeability, ability to create multilayer systems, and maintenance of the spatial structure by retaining aqueous solutions in the interchain voids [1,[21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Functional Properties of Two-Component Hydrogel Systems Based on Gelatin and Polyvinyl Alcohol—Experimental Studies Supported by Computational Analysis

Labus

Radosiński

Kotowski

2021

IJMS

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The presented research is focused on an investigation of the effect of the addition of polyvinyl alcohol (PVA) to a gelatin-based hydrogel on the functional properties of the resulting material. The main purpose was to experimentally determine and compare the properties of hydrogels differing from the content of PVA in the blend. Subsequently, the utility of these matrices for the production of an immobilized invertase preparation with improved operational stability was examined. We also propose a useful computational tool to predict the properties of the final material depending on the proportions of both components in order to design the feature range of the hydrogel blend desired for a strictly specified immobilization system (of enzyme/carrier type). Based on experimental research, it was found that an increase in the PVA content in gelatin hydrogels contributes to obtaining materials with a visibly higher packaging density, degree of swelling, and water absorption capacity. In the case of hydrolytic degradation and compressive strength, the opposite tendency was observed. The functionality studies of gelatin and gelatin/PVA hydrogels for enzyme immobilization indicate the very promising potential of invertase entrapped in a gelatin/PVA hydrogel matrix as a stable biocatalyst for industrial use. The molecular modeling analysis performed in this work provides qualitative information about the tendencies of the macroscopic parameters observed with the increase in the PVA and insight into the chemical nature of these dependencies.

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Section: Preparation Of Molecular Models Of Hydrogel Structuressupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Functional Properties of Two-Component Hydrogel Systems Based on Gelatin and Polyvinyl Alcohol—Experimental Studies Supported by Computational Analysis

Labus

Radosiński

Kotowski

2021

IJMS

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“…Ideally, the degradation rate should match the rate of new tissue formation and remodeling. The rate of biodegradability can be tailored using different strategies, including changing the crosslinking degree between polymer chains, blending/combining different types of polymers at different ratios, or introducing protease sensitive chemical functional groups [ 54 , 55 , 57 , 60 , 68 , 69 ]. ECM derived protein-based polymers, such as collagen and gelatin, are commonly used to generate biodegradable hydrogels [ 70 ].…”

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

Functional Hydrogels for Treatment of Chronic Wounds

Firlar

Altunbek

McCarthy

et al. 2022

Gels

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Chronic wounds severely affect 1–2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.

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“…The wide variety of preparation techniques and starting materials that are readily available for the synthesis of hydrogels enable the use of these polymers in a wide range of applications 2 including, but not limited to, tissue engineering, biomedical, and sensing applications. Mainly, hydrogels are excellent biomaterials as they can mimic the biphasic (water and polymer) natural environment in biological systems 3 ; the capability to synthesize, modify, or blend with natural or synthetic components to mimic extracellular matrix, biocompatibility, and biodegradability make hydrogels ideal for tissue engineering applications 4 ; the “smart hydrogels” that can respond to external stimuli, such as pH, temperature, molecules, solvents, mechanical force, and light are widely used as sensors; the stimuli responsiveness, excellent transportation properties, and injectability support the use of these gels as drug delivery systems 5–7 …”

Section: Introductionmentioning

confidence: 99%

Synthetic hydrogels: Synthesis, novel trends, and applications

Madduma‐Bandarage

Madihally

2020

J of Applied Polymer Sci

254

167

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Hydrogels have been generated and explored for use in various applications. The main objective of this comprehensive review is to collate the fundamental concepts of hydrogels, and elaborate on knowledge gaps, and to provide a perspective on the future directions. This review includes details of constituent molecules (monomers, cross‐linkers, composite materials, etc.) and the methods used to prepare polymer networks. Moreover, the review highlights modifications of hydrogels that introduce new properties or enhance the existing features to suit the desired applications and challenges of synthetic polymer hydrogels. The other important topics covered in this review are the synthesis and applications of 3D printed hydrogels, nanocomposite hydrogels, injectable hydrogels, and self‐healing hydrogels.

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Strategies toward development of biodegradable hydrogels for biomedical applications

Cited by 15 publications

References 78 publications

Functional Properties of Two-Component Hydrogel Systems Based on Gelatin and Polyvinyl Alcohol—Experimental Studies Supported by Computational Analysis

Functional Properties of Two-Component Hydrogel Systems Based on Gelatin and Polyvinyl Alcohol—Experimental Studies Supported by Computational Analysis

Functional Hydrogels for Treatment of Chronic Wounds

Synthetic hydrogels: Synthesis, novel trends, and applications

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