Strategies to optimize photosensitizers for photodynamic inactivation of bacteria

Maisch, Tim

doi:10.1016/j.jphotobiol.2015.05.010

Cited by 156 publications

(71 citation statements)

References 88 publications

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“…Due to ROS-mediated targeting of microbial membranes, membrane proteins, DNA, etc., of various pathogens, PACT represents a broad-spectrum multitargeted approach with very limited, if any, chances for the development of resistant bacteria or viruses (Jori et al 2006, Tavares et al 2010Costa et al 2012b;Dosselli et al 2012;Maisch 2015). PACT has been applied successfully to inactivate bacteria, fungi, protozoans and parasites, especially in topical applications such as skin wounds (burns and diabetic foot ulcers) or oral infections (periodontitis and root canal infections) (Tim 2015). The success of antibacterial PDT depends upon more rapid PS uptake in bacteria in comparison to host cells (Wainwright et al 2017).…”

Section: Photodynamic Antimicrobial Activitymentioning

confidence: 99%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

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Photodynamic therapy (PDT) combines a photosensitiser, light and molecular oxygen to induce oxidative stress that can be used to kill pathogens, cancer cells and other highly proliferative cells. There is a growing number of clinically approved photosensitisers and applications of PDT, whose main advantages include the possibility of selective targeting, localised action and stimulation of the immune responses. Further improvements and broader use of PDT could be accomplished by designing new photosensitisers with increased selectivity and bioavailability. Porphyrin-based photosensitisers with amphiphilic properties, bearing one or more positive charges, are an effective tool in PDT against cancers, microbial infections and, most recently, autoimmune skin disorders. The aim of the review is to present some of the recent examples of the applications and research that employ this specific group of photosensitisers. Furthermore, we will highlight the link between their structural characteristics and PDT efficiency, which will be helpful as guidelines for rational design and evaluation of new PSs.

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Section: Photodynamic Antimicrobial Activitymentioning

confidence: 99%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

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“…Fullerene itself acts as an antioxidant and prevents premature skin aging. [225][226][227][228][229] Fullerene delivers vitamins to effectively enhance the skin. Recently, some researchers developed a fullerene nanocapsule with ascorbic acid and vitamin E. It showed enhanced skin protective activity against premature aging by its antioxidant activities.…”

Section: Fullerenementioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

135

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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“…Accumulating selectively in diseased tissue and, via generation of cytotoxic species, PS provokes the desired biological effect, without causing excessive damage to the host tissue. In general, a PS used for antimicrobial PDT should be endowed with the following properties [11]: (i) high triplet-state quantum yields (Φτ ≥ 0.5), triplet-state with lifetimes long enough (τ microsecond range), and sufficiently energetic (≥94 kJ/mol) to produce 1 O 2 (ΦΔ ≥ 0.5); (ii) high-binding affinity for microorganism (positively charged PS for good adherence to negatively charged bacterial cell wall) and low-binding affinity for mammalian cells; (iii) broad spectrum of action, since one photosensitizer can act on bacteria, fungi, yeasts, and parasitic protozoa; (iv) minimum dark toxicity and negligible cytotoxicity in the absence of light; (v) not yield toxic and mutagenic Can Nanotechnology Shine a New Light on Antimicrobial Photodynamic Therapies?…”

Section: Antimicrobial Efficacy Of Pdt: the Photosensitizersmentioning

confidence: 99%

Can Nanotechnology Shine a New Light on Antimicrobial Photodynamic Therapies?

Bloise¹,

Minzioni²,

Imbriani³

et al. 2017

Photomedicine - Advances in Clinical Practice

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Recent developments in light-controlled therapies (e.g., photodynamic and photothermal therapies) provide promising strategies to prevent and suppress bacterial infections, which are a leading cause of morbidity and mortality. Antibacterial photodynamic therapy (aPDT) has drawn increasing attention from the scientific society for its potential to kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance. In this chapter, we summarize the mechanism of action of aPDT, the photosensitizers, as well the current developments in terms of treating Gram-positive and Gram-negative bacteria. The chapter also describes the recent progress relating to photomedicine for preventing bacterial infections and biofilm formation. We focus on the laser device used in aPDT and on the light-treatment parameters that may have a strong impact on the results of aPDT experiments. In the last part of this chapter, we survey on the various nanoparticles delivering photoactive molecules, and photoactive-nanoparticles that can potentially enhance the antimicrobial action of aPDT.

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Strategies to optimize photosensitizers for photodynamic inactivation of bacteria

Cited by 156 publications

References 88 publications

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Can Nanotechnology Shine a New Light on Antimicrobial Photodynamic Therapies?

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