Strategies to Improve Cannabidiol Bioavailability and Drug Delivery

O’Sullivan, Saoirse Elizabeth; Jensen, Sanne Skov; Kolli, Aditya Reddy; Nikolajsen, Gitte Nykjær; Bruun, Heidi Ziegler; Hoeng, Julia

doi:10.3390/ph17020244

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…On the other hand, transdermal route of CBD administration delivers the drug systemically in a slower manner, gradually over time. 13 Prescribed cannabinoids include the oromucosal spray nabiximols (Cannabis-based extract with CBD:THC in a 1:1 ratio) and capsules with the synthetic analogue of THC -dronabinol or nabilone. [10][11][12] Cannabinoids' beneficial features have given them a new therapeutic meaning in the treatment of a wide range of conditions.…”

Section: Introductionmentioning

confidence: 99%

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

Sobieraj,

Strzelecka,

Sobczak

et al. 2024

IJN

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Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms and inflammatory reactions of the organism, thus inevitably affecting maintenance of homeostasis. Medical Cannabis popularity has surged since its legal regulation growing around the world. Numerous promising discoveries bring more data on cannabinoids’ pharmacological characteristics and therapeutic applications. Given the current surge in interest in the medical use of cannabinoids, there is an urgent need for an effective method of their administration. Surpassing low bioavailability, low water solubility, and instability became an important milestone in the advancement of cannabinoids in pharmaceutical applications. The numerous uses of cannabinoids in clinical practice remain restricted by limited administration alternatives, but there is hope when biodegradable polymers are taken into account. The primary objective of this review is to highlight the wide range of indications for which cannabinoids may be used, as well as the polymeric carriers that enhance their effectiveness. The current review described a wide range of therapeutic applications of cannabinoids, including pain management, neurological and sleep disorders, anxiety, and cancer treatment. The use of these compounds was further examined in the area of dermatology and cosmetology. Finally, with the use of biodegradable polymer-based drug delivery systems (DDSs), it was demonstrated that cannabinoids can be delivered specifically to the intended site while also improving the drug’s physicochemical properties, emphasizing their utility. Nevertheless, additional clinical trials on novel cannabinoids’ formulations are required, as their full spectrum therapeutical potential is yet to be unravelled.

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