Strategies to Improve Antibiotic Use

Bryan, Charles S.

doi:10.1016/s0891-5520(20)30304-4

Cited by 23 publications

(1 citation statement)

References 48 publications

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“…Four types of intervention strategies to improve drug use can be applied: educational, managerial, financial and regulatory (17). These strategies include education, control of the hospital formulary, written justification forms, automatic stop order ongoing utilization review, restriction, required consultation, control of laboratory susceptibility testing, and limitation of contact time between physicians and pharmaceutical representatives (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Changes in Antibiotic Use, Cost and Consumption after an Antibiotic Restriction Policy Applied by Infectious Disease Specialists

Ozkurt,

Erol,

Kadanali

et al. 2005

Jpn J Infect Dis

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The study was designed to compare antibiotic use, cost and consumption before and after an initiation of an antibiotic-restriction policy in our hospital. The policy was applied in 2003, and the prescription of two groups of antibiotics (intravenously used and expensive antibiotics) was restricted. A prescription for the restricted antibiotics could be obtained with approval by an infectious disease specialist (IDS). All the hospitalized patients who received antibiotics were evaluated by a cross-sectional study with standard criteria. The annual cost and consumption of antibiotics were evaluated. After restriction, the rate of antibiotic use decreased from 52.7 to 36.7% (P < 0.001), and the appropriate use increased from 55.5 to 66.4% (P < 0.05). Appropriate use was higher for restricted antibiotics (88.4%) than for unrestricted ones (58.2%) (P < 0.001), and higher in the presence of ID consultation (97.5%) than in the absence of consultation (55.7%) (P < 0.001). Culture-based treatment was increased, and appropriate use in such cases (93.0%) was higher than empirical treatment (33.3%) (P < 0.001). After the restriction policy, consumption of antibiotics belonging to the restricted groups was decreased by 44.8%. Total expenditure of all antibiotics was decreased by 18.5%, and the savings were US$332,000 per year. This restriction policy was effective in promoting rational antibiotic prescription and lowering antibiotic cost and consumption in our hospital.

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