Strategies to engineer tendon/ligament-to-bone interface: Biomaterials, cells and growth factors

Tellado, Sònia Font; Balmayor, Elizabeth R.; Griensven, Martijn van

doi:10.1016/j.addr.2015.03.004

Cited by 206 publications

(222 citation statements)

References 188 publications

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“…34,35 In this study, the interactions between MC3T3-E1 cells and the m-MS/PBSu composite scaffolds in 3D environments were studied, and the cell viability on the scaffolds was evaluated using the CCK-8 assay and the live/dead kit. The results showed that the number of live cells on C40 was the highest while that on C0 was the lowest.…”

Section: àmentioning

confidence: 99%

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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Bioactive scaffolds of magnesium silicate (m-MS)/poly(butylene succinate) (PBSu) composites were fabricated by a solvent casting-particulate leaching method for bone regeneration. The scaffolds had a hierarchical porous structure with interconnected macropores (300-500 mm), micropores (1-10 mm) and mesopores (B5 nm). In addition, the composite scaffolds were degradable in Tris-HCl solution and The results demonstrated that the bioactive m-MS/PBSu composite scaffolds with good biocompatibility, degradability, bioactivity and osteogenesis are promising biomaterials for bone repair.

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Section: àmentioning

confidence: 99%

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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“…All relevant manuscripts were accessed and articles that combined tissue engineering approaches for both tendons and ligaments were included. Articles that discussed different tissue engineering approaches of the tendon/ligament to bone interface were also excluded due to the broadness of the topic and the important number of review articles on the subject [8,[22][23][24].…”

Section: Materials and Methodologymentioning

confidence: 99%

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Alshomer

Chaves

Kalaskar

2018

Journal of Materials

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Introduction. Tendons are specialised, heterogeneous connective tissues, which represent a significant healthcare challenge after injury. Primary surgical repair is the gold standard modality of care; however, it is highly dependent on the extent of injuries. Tissue engineering represents an alternative solution for good tissue integration and regeneration. In this review, we look at the advanced biomaterial composites employed to improve cellular growth while providing appropriate mechanical properties for tendon and ligament repair. Methodology. Comprehensive literature searches focused on advanced composite biomaterials for tendon and ligament tissue engineering. Studies were categorised depending on the application. Results. In the literature, a range of natural and/or synthetic materials have been combined to produce composite scaffolds tendon and ligament tissue engineering. In vitro and in vivo assessment demonstrate promising cellular integration with sufficient mechanical strength. The biological properties were improved with the addition of growth factors within the composite materials. Most in vivo studies were completed in smallscale animal models. Conclusions. Advanced composite materials represent a promising solution to the challenges associated with tendon and ligament tissue engineering. Nevertheless, these approaches still demonstrate limitations, including the necessity of larger-scale animal models to ease future clinical translation and comprehensive assessment of tissue response after implantation.

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“…Taking this complex hierarchical organization into consideration, various models for scaffolds and grafts have been proposed for the repair of the tendon/ligament-bone interface (Figure 2) (Tellado et al, 2015). However, the scaffolds designed for tendon/ligament interfaces are often far from representing the physiological structure, as they are designed as layers with or without minerals (Moffat et al, 2009;Kim et al, 2014).…”

Section: Tendon/ligament-bone Interfacementioning

confidence: 99%

Engineering Musculoskeletal Tissue Interfaces

Bayrak

Huri

2018

Front. Mater.

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Tissue engineering aims to bring together biomaterials, cells, and signaling molecules within properly designed microenvironments in order to create viable treatment options for the lost or malfunctioning tissues. Design and production of scaffolds and cell-laden grafts that mimic the complex structural and functional features of tissues are among the most important elements of tissue engineering strategy. Although all tissues have their own complex structure, an even more complex case in terms of engineering a proper carrier material is encountered at the tissue interfaces, where two distinct tissues come together. The interfaces in the body can be examined in four categories; cartilage-bone and ligament-bone interfaces at the knee and the spine, tendon-bone interfaces at the shoulder and the feet, and muscle-tendon interface at the skeletal system. These interfaces are seen mainly at the soft-to-hard tissue transitions and they are especially susceptible to injury and tear due to the biomechanical inconsistency between these tissues where high strain fields are present. Therefore, engineering the musculoskeletal tissue interfaces remain a challenge. This review focuses on recent advancements in strategies for musculoskeletal interface engineering using different biomaterial-based platforms and surface modification techniques.

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Strategies to engineer tendon/ligament-to-bone interface: Biomaterials, cells and growth factors

Cited by 206 publications

References 188 publications

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Engineering Musculoskeletal Tissue Interfaces

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