Strategies to eliminate hepatitis C in Croatia, a modelling study

Vince, Adriana; Dugan, Ellen; Nemeth-Blažić, Tatjana; Filipec, Tajana; Hrstić, Irena; Lukšić, Boris; Nonković, Diana; Reic, Tatjana; Coleman, Samantha; Razavi, Homie; Blach, Sarah

doi:10.26800/lv-142-9-10-44

Cited by 2 publications

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“…Major changes have been implemented in HCV treatment strategies in Croatia in the last several years. Treatment eligibility was expanded to include patients aged 18–84 years, regardless of fibrosis stage, and the annual treated number of patients tripled from 2015 to 2018 [ 20 ]. However, some quasispecies variants bear polymorphisms in drug-targeted genes, which may negatively impact antiviral treatment and confer resistance to direct acting antivirals in 5–10% of the patients [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Epidemiology and Baseline Resistance of Hepatitis C Virus to Direct Acting Antivirals in Croatia

et al. 2022

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Molecular epidemiology of hepatitis C virus (HCV) is exceptionally complex due to the highly diverse HCV genome. Genetic diversity, transmission dynamics, and epidemic history of the most common HCV genotypes were inferred by population sequencing of the HCV NS3, NS5A, and NS5B region followed by phylogenetic and phylodynamic analysis. The results of this research suggest high overall prevalence of baseline NS3 resistance associate substitutions (RAS) (33.0%), moderate prevalence of NS5A RAS (13.7%), and low prevalence of nucleoside inhibitor NS5B RAS (8.3%). Prevalence of RAS significantly differed according to HCV genotype, with the highest prevalence of baseline resistance to NS3 inhibitors and NS5A inhibitors observed in HCV subtype 1a (68.8%) and subtype 1b (21.3%), respectively. Phylogenetic tree reconstructions showed two distinct clades within the subtype 1a, clade I (62.4%) and clade II (37.6%). NS3 RAS were preferentially associated with clade I. Phylogenetic analysis demonstrated that 27 (9.0%) HCV sequences had a presumed epidemiological link with another sequence and classified into 13 transmission pairs or clusters which were predominantly comprised of subtype 3a viruses and commonly detected among intravenous drug users (IDU). Phylodynamic analyses highlighted an exponential increase in subtype 1a and 3a effective population size in the late 20th century, which is a period associated with an explosive increase in the number of IDU in Croatia.

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Section: Introductionmentioning

confidence: 99%

Molecular Epidemiology and Baseline Resistance of Hepatitis C Virus to Direct Acting Antivirals in Croatia

et al. 2022

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“…Результати дослідження ефективності противірусної терапії ГС висвітлено і в статтях інших авторів [7,8]. На шляху до реалізації глобальної стратегії ВООЗ з боротьби з пандемією вірусного гепатиту вчені розглядають епідеміологію та прогнозують тенденції в діагностиці, лікуванні ГС у Франції, Німеччині, Італії, Іспанії, Великобританії [7], Хорватії [9] та деяких інших країнах Європейського регіону ВООЗ [10][11][12], Африканського регіону [13], регіону країн Азії та Тихого океану [14], регіонах країн Америки [15,16]. Попередні дослідження авторів [17] також мали на меті аналіз епідеміологічних показників ГС у регіонах світу.…”

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Analysis of the world experience in countering the spread of hepatitis C among the population as a component of developing programs to increase the availability of pharmaceutical care

Volkova¹,

Nozdrina²

2022

Soc. pharm. health care

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Aim. To analyze the world experience in countering viral hepatitis C as a component of developing programs to increase the availability of pharmaceutical care grouping countries by their level of economic development and belonging to the WHO region. Materials and methods. The study materials were statistical reports of the WHO, national reports of countries on the prevalence, morbidity, and measures to counteract hepatitis C, as well as reports of the Polaris global study. Desk-based research methods, such as content analysis, systematic, logical, as well as methods of comparative analysis and generalization, were used.

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Strategies to eliminate hepatitis C in Croatia, a modelling study

Cited by 2 publications

References 0 publications

Molecular Epidemiology and Baseline Resistance of Hepatitis C Virus to Direct Acting Antivirals in Croatia

Molecular Epidemiology and Baseline Resistance of Hepatitis C Virus to Direct Acting Antivirals in Croatia

Analysis of the world experience in countering the spread of hepatitis C among the population as a component of developing programs to increase the availability of pharmaceutical care

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