Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

Lince, Federica; Marchisio, Daniele

doi:10.1016/j.jcis.2008.03.033

Cited by 209 publications

(182 citation statements)

References 24 publications

(32 reference statements)

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“…The size of NPs was dependent of the type of non-solvent and increased in the following order: methanol < ethanol < propanol. Lince et al (2008) prepared poly-ɛ-caprolactone (PCL) nanoparticles in a Confined Impinging Jets Reactor (CIJR) and found a significant effect of mixing on the final particle size. The mixing efficiency increased with increasing the flow rate of the liquid phases entering the CIJR, which favoured nucleation and led to a marked reduction in the particle size.…”

Section: Introductionmentioning

confidence: 99%

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

Othman

Vladisavljević

Nagy

2015

Chemical Engineering Science

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The aim of this study was to develop a new microfluidic approach for the preparation of nanoparticles with tuneable sizes based on micromixing / direct nanoprecipitation in a coaxial assembly of tapered-end glass capillaries. The organic phase was 1 wt% poly(-caprolactone) (PCL) or poly(dl-lactic acid) (PLA) in tetrahydrofuran and the antisolvent was Milli-Q water.The size of nanoparticles was precisely controlled over a range of 190-650 nm by controlling phase flow rates, orifice size and flow configuration (two-phase co-flow or countercurrent flow focusing). Smaller particles were produced in a flow focusing device, because the organic phase stream was significantly narrower than the orifice and remained narrow for a longer distance downstream of the orifice. The mean size of PCL particles produced in a flow focusing device with an orifice size of 200 m, an organic phase flow rate of 1.7 mL h -1 and an aqueous-toorganic flow rate ratio of 10 was below 200 nm. The size of nanoparticles decreased with decreasing the orifice size and increasing the aqueous-to-organic phase flow rate ratio. Due to *Revised Manuscript Click here to view linked References 2 higher affinity for water and amorphous structure, PLA nanoparticles were smaller and exhibited a smoother surface and more rounded shape than PCL particles.

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Section: Introductionmentioning

confidence: 99%

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

Othman

Vladisavljević

Nagy

2015

Chemical Engineering Science

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“…[46][47][48] In the present study, NPs were produced with PCL; this polymer has a negative electrokinetic potential, probably due to the presence of some residual functional groups with negative charges on the monomer employed in PCL polymerization. 44 After the loading process and the anodic stimulation, we detected a modification of the zeta potential, but the NPs remained negatively charged. As shown in Table 2, these values varied between −1.38 and −2.10 mV.…”

Section: Discussionmentioning

confidence: 91%

“…43 Furthermore, the loading yield is comparable to other findings in the literature 4,17 and is probably due to the low solubility of L-tyrosine in PBS aqueous phase. The surface charge of NPs can be characterized by the zeta potential, 44 which reflects the electric potential of particles and is influenced by their chemical composition as well as the medium in which they are dispersed. 2 To assess the influence of AF stimulation on the surface charge of the NPs, zeta potentials were also measured before and after a 6-min AF exposure for both preparations (loaded-and unloadedNPs).…”

Section: Discussionmentioning

confidence: 99%

L-Tyrosine-loaded nanoparticles increase the antitumoral activity of direct electric current in a metastatic melanoma cell model

Campos

Teixeira²,

Veiga³

et al. 2010

IJN

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Inhibition of tumor growth induced by treatment with direct electric current (DC) has been reported in several models. One of the mechanisms responsible for the antitumoral activity of DC is the generation of oxidative species, known as chloramines. With the aim of increasing chloramine production in the electrolytic medium and optimizing the antitumoral effects of DC, poly(ε-caprolactone) (PCL) nanoparticles (NPs) loaded with the amino acid tyrosine were obtained. The physical-chemical characterization showed that the NPs presented size in nanometric range and monomodal distribution. A slightly negative electrokinetic potential was also found in both blank NPs and l-tyrosine-loaded PCL NPs. The yield of the loading process was approximately 50%. Within 3 h of dissolution assay, a burst release of about 80% l-tyrosine was obtained. The in vitro cytotoxicity of DC was significantly increased when associated with l-tyrosine-loaded NPs, using a murine multidrug-resistant melanoma cell line model. This study showed that the use of the combination of nanotechnology and DC has a promising antineoplastic potential and opens a new perspective in cancer therapy.

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“…[8][9][10][11][12] In this way, the homogeneity of the population on the nanometric scale, the average size and the polydispersity are key characteristics to reach potential applicable formulations in therapeutics. So, the ability to cross biological barriers in a selective manner is dependent on the control of the granulometry and the homogeneity of particle sizes.…”

Section: 245mentioning

confidence: 99%

Lipid-core nanocapsules: mechanism of self-assembly, control of size and loading capacity

et al. 2012

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Nanotechnology in pharmaceutics has the potential to improve drug efficacy by influencing drug distribution in tissues. Nanocarriers have been developed as drug delivery systems to be administered by different biological routes. To ensure the nanotechnological properties, pre-formulation studies are especially critical in determining the influence of the process parameters on the size and polydispersity of particles. Thus, the objective of this work was to establish the mechanism of self-assembly, by determining the influence of the critical aggregation concentration of the materials in the organic phase on the final average particle size and polydispersity of polymeric lipid-core nanocapsules obtained by interfacial deposition of polymer. Measurements of the surface tension and viscosity of the organic and aqueous phases were correlated with the particle size and the concentration of raw materials. We demonstrated that the lipid-core nanocapsules are formed on the nanoscopic scale as unimodal distributions, if the aggregation state of raw materials in the organic phase tends to infinite dilution. The strategy for controlling the particle size distribution is a valuable tool in producing lipid-core nanocapsule formulations with different loading capacities intended for therapeutics.

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Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

Cited by 209 publications

References 24 publications

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

L-Tyrosine-loaded nanoparticles increase the antitumoral activity of direct electric current in a metastatic melanoma cell model

Lipid-core nanocapsules: mechanism of self-assembly, control of size and loading capacity

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