2021
DOI: 10.3390/antiox10030444
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Strategies to Broaden the Applications of Olive Biophenols Oleuropein and Hydroxytyrosol in Food Products

Abstract: Oleuropein (OLE) and hydroxytyrosol (HT) are olive-derived phenols recognised as health-promoting agents with antioxidant, anti-inflammatory, cardioprotective, antifungal, antimicrobial, and antitumor activities, providing a wide range of applications as functional food ingredients. HT is Generally Recognised as Safe (GRAS) by the European Food Safety Authority (EFSA) and the Food and Drug Administration (FDA), whereas OLE is included in EFSA daily consumptions recommendations, albeit there is no official GRAS… Show more

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Cited by 21 publications
(11 citation statements)
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“…Lipophilic derivatives [ 57 , 58 , 59 , 60 , 61 ] and novel compounds were synthetized without modifying the catecholic moiety to be tested in vitro and in vivo as antioxidant, anticancer, anti-inflammatory, and neuroprotective agents [ 62 , 63 , 64 , 65 ]. Emerging research is devoted to developing drug delivery systems based on liposomes [ 66 ] and nanotechnology [ 67 ] for a better bioavailability and improved biological activities of both HTyr and OLE [ 68 ].…”
Section: Chemistry Of Hydroxytyrosol (Htyr) and Oleuropein (Ole)mentioning
confidence: 99%
“…Lipophilic derivatives [ 57 , 58 , 59 , 60 , 61 ] and novel compounds were synthetized without modifying the catecholic moiety to be tested in vitro and in vivo as antioxidant, anticancer, anti-inflammatory, and neuroprotective agents [ 62 , 63 , 64 , 65 ]. Emerging research is devoted to developing drug delivery systems based on liposomes [ 66 ] and nanotechnology [ 67 ] for a better bioavailability and improved biological activities of both HTyr and OLE [ 68 ].…”
Section: Chemistry Of Hydroxytyrosol (Htyr) and Oleuropein (Ole)mentioning
confidence: 99%
“…A small natural polyphenol which has antiviral activity is hydroxytyrosol [ 103 ], which can be captured in the hydrophobic cavity of -cyclodextrins [ 206 ]. The study evidenced that -cyclodextrin interacts with Spike and ACE2 proteins; moreover, hydroxytyrosol interacts with Spike and ACE2 proteins, even if -cyclodextrin results a better inhibitor than hydroxytyrol against ACE2 protein.…”
Section: Nanomaterials For Covid-19 Prevention and Treatmentmentioning
confidence: 99%
“…The applications of hydroxytyrosol in emulsified systems may be hindered by challenges such as degradation caused by processing conditions. To overcome such shortcomings, the noncovalent and covalent complexations of hydroxytyrosol have been reported to play a significant role in its antioxidant properties (Monteiro et al, 2021). Pham et al (2019) prepared the hydroxytyrosolflaxseed protein isolate complexes as an emulsifier in oilin-water emulsions and found that the complexes showed an antioxidant activity of 80% inhibition against the formation of hydroperoxides at 20 • C, compared to the activity of 18% for the emulsions with flaxseed protein isolate alone.…”
Section: Hydroxytyrosolmentioning
confidence: 99%
“…The applications of hydroxytyrosol in emulsified systems may be hindered by challenges such as degradation caused by processing conditions. To overcome such shortcomings, the noncovalent and covalent complexations of hydroxytyrosol have been reported to play a significant role in its antioxidant properties (Monteiro et al., 2021). Pham et al.…”
Section: Phenolic Antioxidantsmentioning
confidence: 99%