Strategies to ameliorate endothelial dysfunction associated with metabolic syndrome, where are we?

Shayo, Sigfrid Casmir; Kawade, Shigeru; Ogiso, Kazuma; Nishio, Yoshihiko

doi:10.1016/j.dsx.2019.05.005

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…Metabolic syndrome is a systematic metabolic dysfunction that involves insulin resistance, visceral adiposity, dyslipidemia, and hypertension (40). Insulin resistance is known to be the primary mechanism (41,42), while other underlying mechanisms including oxidative stress (43), inflammation (44,45), and endothelial dysfunction (46) are also discussed in literature. As is indicated by the criteria for clinical diagnosis of metabolic syndrome, abnormal carbohydrate and lipid metabolism are highly associated with this syndrome (5).…”

Section: Discussionmentioning

confidence: 99%

Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and Systematic Review

Liu

et al. 2020

Front. Nutr.

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Background and Aims:Cyclocarya paliurus (CP) has been used as an herbal tea to treat diabetes mellitus and obesity for hundreds of years. Previous research suggests that CP specifically restores glucolipid metabolic homeostasis, and the two most studied preparations are aqueous and ethanol extracts. In order to verify the effect of CP on glucolipid metabolism in animal models with metabolic syndrome, a meta-analysis was performed, and the active components and underlying mechanisms were systematically reviewed.Methods: Four databases: PubMed, Web of Science, Embase, and Cochrane Library were searched to identify potential literature. Data of blood glucose (BG) level, area under curve (AUC) of oral glucose tolerance test (OGTT), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels were extracted as indicators of the assessment of CP's effects. Follow-up analyses including subgroup analysis, meta-regressions, and publication bias were also conducted.Results: A total of 96 papers were identified from the databases and 11 papers including 31 data reports were involved in the meta-analysis. CP had a positive effect in down-regulating BG, AUC of OGTT, TC, TG, and LDL, and up-regulating HDL (P < 0.001, 95% confidence interval of standard mean difference did not incorporate the null value 0).Conclusion: CP showed definite activity of regulating glucolipid metabolism in animal models, and it exerted its function through multiple mechanisms including but not limited to: (1) improving insulin resistance; (2) protecting pancreatic β cells; (3) decreasing inflammatory infiltration; and (4) anti-oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and Systematic Review

Liu

et al. 2020

Front. Nutr.

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“…Endothelial dysfunction is druggable and can respond to some pharmacological treatments such as the use of sulodexide or mesoglycan, which have pleiotropic effects on the vascular system including anti-inflammatory, endothelial protective, and vasoregulatory effects [103][104][105]. In this regard, a study showed a preventive effect on varicose vein development after MCP-1 expression suppression [106].…”

Section: The Role Of Endothelial Dysfunction In Cvdmentioning

confidence: 99%

Molecular Determinants of Chronic Venous Disease: A Comprehensive Review

Costa

Andreucci

Ielapi

et al. 2023

IJMS

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Chronic Venous Disease (CVD) refers to several pathological and hemodynamic alterations of the veins of lower limbs causing a wide range of symptoms and signs with a high prevalence in the general population and with disabling consequences in the most severe forms. The etiology and pathophysiology of CVD is complex and multifactorial, involving genetic, proteomic, and cellular mechanisms that result in changes to the venous structure and functions. Expressions of several genes associated with angiogenesis, vascular development, and the regulation of veins are responsible for the susceptibility to CVD. Current evidence shows that several extracellular matrix alterations (ECM) could be identified and in some cases pharmacologically targeted. This review shows the most up to date information on molecular determinants of CVD in order to provide a complete overview of the current knowledge on this topic. In particular, the article explores the genetic influence, the hormonal influence, ECM imbalance, and histopathology of CVD and the role of endothelial dysfunction in CVD.

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“…The main causes of endothelial dysfunction are related to the metabolic alterations of T2DM, to dyslipidemia and to chronic low-grade inflammatory state [31]. Several NBCs seem to counteract and improve endothelial damage (Table 4) [201]. The NCBs present in garlic have been extensively studied for their hypotensive function.…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

et al. 2021

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Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.

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Strategies to ameliorate endothelial dysfunction associated with metabolic syndrome, where are we?

Cited by 8 publications

References 23 publications

Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and Systematic Review

Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and Systematic Review

Molecular Determinants of Chronic Venous Disease: A Comprehensive Review

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

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