Strategies of Immobilizing BMP-2 with 3D-printed Scaffolds to Improve Osteogenesis

Bi, Zhiguo; Shi, Xiaorui; Liao, Shiyu; Li, Xiao; Sun, Chao; Liu, Jianguo

doi:10.2217/rme-2022-0222

Cited by 6 publications

(1 citation statement)

References 135 publications

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“…By the 12th week, the expression level of OCN protein in the MB group remained higher than that in the control group, but the expression of BMP-2 was lower than that in the control group. Considering that BMP-2 is an osteogenic growth factor that promotes bone formation (Zhang et al, 2019;Bi et al, 2023), this result suggests that the strong bone-promoting effect in the control group was achieved at 12 weeks, later than in the MB group.…”

Section: Osseointegration Of the Porous Scaffold With Surrounding Bonementioning

confidence: 89%

“Metal-bone” scaffold for accelerated peri-implant endosseous healing

Lu,

Wang,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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Restoring bone defects caused by conditions such as tumors, trauma, or inflammation is a significant clinical challenge. Currently, there is a need for the development of bone tissue engineering scaffolds that meet clinical standards to promote bone regeneration in these defects. In this study, we combined the porous Ti6Al4V scaffold in bone tissue engineering with advanced bone grafting techniques to create a novel “metal-bone” scaffold for enhanced bone regeneration. Utilizing 3D printing technology, we fabricated a porous Ti6Al4V scaffold with an average pore size of 789 ± 22.69 μm. The characterization and biocompatibility of the scaffold were validated through in vitro experiments. Subsequently, the scaffold was implanted into the distal femurs of experimental animals, removed after 3 months, and transformed into a “metal-bone” scaffold. When this “metal-bone” scaffold was re-implanted into bone defects in the animals, the results demonstrated that, in comparison to a plain porous Ti6Al4V scaffold, the scaffold containing bone tissue achieved accelerated early-stage bone regeneration. The experimental group exhibited more bone tissue generation in the early stages at the defect site, resulting in superior bone integration. In conclusion, the “metal-bone” scaffold, containing bone tissue, proves to be an effective bone-promoting scaffold with promising clinical applications.

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Section: Osseointegration Of the Porous Scaffold With Surrounding Bonementioning

confidence: 89%