Strategies of Functional Foods Promote Sleep in Human Being

Zeng, Yawen; Yang, Jia-Zhen; Du, Juan; Pu, Xiaoying; Yang, Xiaomen; ShuMing, Yang; Yang, Tao

doi:10.2174/1574362410666150205165504

Cited by 31 publications

(31 citation statements)

References 116 publications

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“…Vitamin D may be involved in the prevention of neurodegenerative disorders; alpha-tocopherol, one of the compounds of the vitamin E group, is involved in nervous membranes protection from oxidative damage [26]. Among minerals, manganese, zinc, and copper participate in enzymatic mechanisms protecting against oxidative stress; iron plays a role for oxygenation, energy production, and neurotransmitters and myelin synthesis in the cerebral parenchyma; and calcium, potassium, and magnesium modulate sleep through the proper functioning of ion channels [27].…”

Section: Role Of Nutritional Components On the Brain: Micro-and Macromentioning

confidence: 99%

Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms

et al. 2020

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Over the last decades, there has been a substantial increase in the prevalence of mental health disorders, including an increased prevalence of depression, anxiety, cognitive, and sleep disorders. Diet and its bioactive components have been recognized among the modifiable risk factors, possibly influencing their pathogenesis. This review aimed to summarize molecular mechanisms underlying the putative beneficial effects toward brain health of different dietary factors, such as micro- and macronutrient intake and habits, such as feeding time and circadian rhythm. The role of hormonal homeostasis in the context of glucose metabolism and adiponectin regulation and its impact on systemic and neuro-inflammation has also been considered and deepened. In addition, the effect of individual bioactive molecules exerting antioxidant activities and acting as anti-inflammatory agents, such as omega-3 fatty acids and polyphenols, considered beneficial for the central nervous system via modulation of adult neurogenesis, synaptic and neuronal plasticity, and microglia activation has been summarized. An overview of the regulation of the gut–brain axis and its effect on the modulation of systemic inflammation and oxidative stress has been provided. Finally, the impact of bioactive molecules on inflammation and oxidative stress and its association with brain health has been summarized.

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Section: Role Of Nutritional Components On the Brain: Micro-and Macromentioning

confidence: 99%

Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms

et al. 2020

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“…11) Over the past few decades, many studies have reported that extracts or active components from natural plants are able to bind to the GABA A -BZD receptor to play a sleep-promoting effect. 12,15) Lettuce and skullcap have been known to be two of the herbs that possess sedative effects, although systematic study on their sleep-promoting effects and relevant mechanism has been insufficient. Traditionally, lettuce has been suggested to have sedative-hypnotic properties.…”

Section: Discussionmentioning

confidence: 99%

“…11) Several natural herbs have been known to have a positive role in sedation or sleep. 12) Valerian (Valeriana officinalis), hops (Humulus lupulus), St. John's wort (Hypericum perforatum), chamomile (Matricaria chamomilla), lingzhi (Ganoderma lucidum), barley grass, and maca are natural herbs commonly used as sedatives and anti-anxiety agents in Europe, the U.S.A., and Asia. 13) These herbs contain complex mixtures of flavonoids, terpenes, and related substances, and are known to cross the blood-brain barrier (BBB) to influence brain function.…”

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confidence: 99%

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Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models

Hong

Han

Park

et al. 2018

Biological & Pharmaceutical Bulletin

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The aim of this study is to investigate the effects of romaine lettuce leaves extract (RE), skullcap root extract (SE) and their mixture on sleep behaviors in vertebrate models. HPLC analysis showed that RE contains lactucopicrin (0.02±0.01 mg/g extract), chlorogenic acid (4.05±0.03 mg/g extract), caffeic acid (2.38±0.03 mg/g extract), and chicoric acid (7.02±0.32 mg/g extract) as main phenolic compounds, while SE includes baicalin (99.4±0.5 mg/g extract), baicalein (8.28±0.21 mg/g extract), and wogonin (3.09±0.32 mg/g extract). The mixture of RE (100 mg/g extract) and SE (40 mg/g extract) increased total sleep time by 50.9% compared with the control in pentobarbital-induced sleep model. In electroencephalography (EEG) analysis, RE/SE mixture significantly increased Non-Rapid Eye Movement (NREM), in which delta wave was enhanced by around 40% compared with normal control, leading to the increase of sleep time. In caffeine-induced wake model, RE/SE mixture greatly decreased (53%) caffeine-induced wake time, showing a similar level to normal control. In addition, caffeine-induced decreased of NREM and delta wave effectively increased with RE/SE mixture; NREM and delta wave increased by 85% and 108%, respectively. Furthermore, RE/SE mixture was shown to bind to a gamma-aminobutyric acid type A (GABA)-benzodiazepine (BZD) receptor stronger than RE or SE single extract. Taken together, RE/SE mixture effectively improved sleep behavior with the increase of NREM via GABA-BZD receptor binding. RE/SE mixture can be used as an herbal agent for sleep disorders.

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“…Barley grass powder with higher GABA, Ca, K, and tryptophan contents is a very effective functional food in promoting sleep [ 70 ]. Sleep symptoms are associated with intake of specific dietary nutrients including Ca (OR = 0.83) and K (OR = 0.70) [ 71 ].…”

Section: Preventive Chronic Disease Of Barley Grassmentioning

confidence: 99%

Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings

Zeng

Yang

et al. 2018

Oxidative Medicine and Cellular Longevity

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Barley grass powder is the best functional food that provides nutrition and eliminates toxins from cells in human beings; however, its functional ingredients have played an important role as health benefit. In order to better cognize the preventive and therapeutic role of barley grass for chronic diseases, we carried out the systematic strategies for functional ingredients of barley grass, based on the comprehensive databases, especially the PubMed, Baidu, ISI Web of Science, and CNKI, between 2008 and 2017. Barley grass is rich in functional ingredients, such as gamma-aminobutyric acid (GABA), flavonoids, saponarin, lutonarin, superoxide dismutase (SOD), K, Ca, Se, tryptophan, chlorophyll, vitamins (A, B1, C, and E), dietary fiber, polysaccharide, alkaloid, metallothioneins, and polyphenols. Barley grass promotes sleep; has antidiabetic effect; regulates blood pressure; enhances immunity; protects liver; has anti-acne/detoxifying and antidepressant effects; improves gastrointestinal function; has anticancer, anti-inflammatory, antioxidant, hypolipidemic, and antigout effects; reduces hyperuricemia; prevents hypoxia, cardiovascular diseases, fatigue, and constipation; alleviates atopic dermatitis; is a calcium supplement; improves cognition; and so on. These results support that barley grass may be one of the best functional foods for preventive chronic diseases and the best raw material of modern diet structure in promoting the development of large health industry and further reveal that GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan mechanism of barley grass have preventive and therapeutic role for chronic diseases. This paper can be used as a scientific evidence for developing functional foods and novel drugs for barley grass for preventive chronic diseases.

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Strategies of Functional Foods Promote Sleep in Human Being

Cited by 31 publications

References 116 publications

Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms

Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms

Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models

Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings

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