1993
DOI: 10.1111/j.1365-2958.1993.tb01155.x
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Strategies in pathogenesis: mechanistic specificity in the detection of generic signals

Abstract: SummaryThe virulence genes of the plant pathogen Agrobacterium tumefaciens are induced by more than 40 lowmolecular-weight phenolic compounds. The prevailing opinion is that (i) wound-derived phenols produced on breach of the integrity of the cell wall act as the initiating signal in a series of events which results in host cell transformation, and (ii) a classical membrane receptor, putatively VirA, is responsible for the recognition of all such phenolic inducers. Here, we argue that the discovery of the subs… Show more

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Cited by 29 publications
(20 citation statements)
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“…Previously, several groups noted that one or two methoxy groups in the ortho position are required, and a wide variety of substituents are permitted in the position para to the hydroxyl group of the phenol (29,38). However, the vir genes of strain KU12 are induced by several compounds, including 4-hydroxyacetophenone, p-coumaric acid, and phenol, that lack any methoxy groups.…”
Section: Discussionmentioning
confidence: 99%
“…Previously, several groups noted that one or two methoxy groups in the ortho position are required, and a wide variety of substituents are permitted in the position para to the hydroxyl group of the phenol (29,38). However, the vir genes of strain KU12 are induced by several compounds, including 4-hydroxyacetophenone, p-coumaric acid, and phenol, that lack any methoxy groups.…”
Section: Discussionmentioning
confidence: 99%
“…The types of phenolic compounds reported to have signal activity include certain acetophenones (e.g. acetosyringone), monolignols, chalcones, and flavonoids (Spencer and Towers, 1988;Zerback et al, 1989;Duban et al, 1993). In the rhizobia, specific plant flavonoids were discovered to activate nodulation (nod) genes essential for establishment of symbiosis (Peters et al, 1986).…”
mentioning
confidence: 99%
“…Table 5 presents the molecular orbital coefficients for each of these pn orbital in basis set I, while Table 6 gives the bare ( l , l~l / r~, 2~1 , 1 ) integral for each Z choice. Notice that the Z = 5.8 orbital yields the smallest (1,l ~l / r~, 2~1 , 1 ) integral because this orbital is the most diffuse spatially. The rather small variation of Z, however, induces changes in the "theoretical" one-center, two-electron integrals which range over 3 eV.…”
Section: Exploratory 97" Calculations For Hexatrienementioning
confidence: 97%
“…This is a common trend in Z" calculations with Rydberg-extended valence spaces.' 1,12,26,28 Unfortunately, the Rydberg-extended valence space barely affects the excitation energy of the l'B, state. As a result, the low-lying singlet 1 'B, states in polyenes may be very difficult to describe using a purely ab initio derived semiempirical method because the ab initio constrained P calculations simply cannot account for all of the correlation in these states with the present third-order treatment.…”
Section: B Constrained Large Basis Set 9p Calculationsmentioning
confidence: 99%