Strategies for utilizing covalent organic frameworks as host materials for the integration and delivery of bioactives

Abstract

This review introduces three strategies (encapsulation, covalent binding and coordinated bonding) for construction of COF-based nanoplatforms for the integration and delivery of bioactives including small molecule, biomacromolecule and exosome.

Encapsulation engineering of porous crystalline frameworks for delayed luminescence and circularly polarized luminescence

“…The porous COFs are similar to MOFs, and host–guest COFs can refer to MOFs, where the confinement and dispersion effect of the channels, pores, structures and aggregation of the guest emitters are similar in COFs. 155,156 However, it should be noted that COFs not only possess a larger internal surface area and permanent porosity, but they also have much higher chemical stability than MOFs, and thus larger guest species can be introduced in their pores. Benefiting from their large pores, guest targets can be immobilized in the skeleton of COFs through post-synthetic modification (PSM), bonding defect functionalization (BDF) and other surface covalence approaches.…”