Strategies for use of blood products for major bleeding in trauma

Wong, Henna; Pottle, Jack; Curry, Nicola; Stanworth, Simon; Brunskill, Susan J; Davenport, Ross; Dorée, Carolyn

doi:10.1002/14651858.cd012635

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Resuscitation in trauma remains controversial in human patients and is an area of active research. More recently there has been increased focus on the use of blood products for definitive volume replacement, particularly when there is massive blood loss ( 27 ).…”

Section: Pulmonary Effects Of Fluid Therapy In Trauma and Lung Contusionsmentioning

confidence: 99%

Fluid Therapy in Pulmonary Disease: How Careful Do We Need to Be?

Adamantos

2021

Front. Vet. Sci.

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Intravenous fluid therapy is a vital and life-saving therapeutic in veterinary medicine. In the absence of heart or lung disease, trauma or sepsis there is limited evidence that fluid therapy will have a detrimental effect on lung function. In healthy dogs there is a reasonable level of experimental evidence that supraphysiologic rates of fluid are required before signs of fluid overload are made evident. In cats, however, this may not be the case. There are higher rates of asymptomatic myocardial disease, but even in the absence of that it seems that some cats may be susceptible to fluid overload. Where systemic inflammation already exists the careful homeostatic and protective mechanisms within the lung are deranged and increases in hydrostatic pressure are more likely to result in fluid movement into the lung tissues. Strategies including restricting the use of intravenous crystalloid fluid administration and using blood products for management of severe hemorrhage are of increasing importance in human trauma and seem to be associated with fewer pulmonary complications, and lower mortality. Managing dogs and cats with sepsis and acute respiratory distress syndrome is already challenging, but ensuring adequate vascular expansion needs to be balanced with avoiding excessive volume administration which may negatively impact pulmonary function. While fluids remain crucial to management of these conditions, there will be an ongoing requirement to balance need without providing excess. The use of point of care ultrasound may provide clinicians with a non-invasive and accessible way to do this.

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Section: Pulmonary Effects Of Fluid Therapy In Trauma and Lung Contusionsmentioning

confidence: 99%

Fluid Therapy in Pulmonary Disease: How Careful Do We Need to Be?

Adamantos

2021

Front. Vet. Sci.

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“…A recent Cochrane project ( 6 ) outlines a protocol whose objective is to assess the effects and safety of blood product transfusion strategies started during the first day post injury for trauma patients of all ages with major bleeding. Clearly, the need to understand and improve the standard of care is warranted, possibly including blood substitutes and/or oxygen carriers.…”

Section: Introductionmentioning

confidence: 99%

Blood substitutes: Basic science, translational studies and clinical trials

Jahr

2022

Front. Med. Technol.

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HemorrhageWhen accident victims are bleeding to death, there have been few medical treatment options to save their lives until they can be rescued and transported to a hospital, despite new campaigns, including use of tranexamic acid as an antifbrinolytic (4).Therefore, work that proposes to develop a new type of fluid, with multiple medical effects, that is designed to improve survival from first-aid treatment by a healthcare professional is warranted. It will include fluids, oxygenating capability (like erythrocytes), blood clotting capability and other essential factors to improve survival-a revolutionary concept for the improvement of current hemorrhagic trauma medical care.

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Strategies for use of blood products for major bleeding in trauma

Cited by 2 publications

References 23 publications

Fluid Therapy in Pulmonary Disease: How Careful Do We Need to Be?

Fluid Therapy in Pulmonary Disease: How Careful Do We Need to Be?

Blood substitutes: Basic science, translational studies and clinical trials

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