Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications

Diane, Umuhoza; Yang, Fang; Long, Dan; Hao, Zhanzhang; Dai, Jing; Zhao, Aichun

doi:10.1021/acsbiomaterials.9b01781

Cited by 54 publications

(39 citation statements)

References 153 publications

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“…For this reason, silk‐based materials have been used in flexible bioelectronics such as cardiac sensors, brain electrodes, electronic skin, as well as, various types of stiff and hard implants. [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

The Manufacture of Unbreakable Bionics via Multifunctional and Self‐Healing Silk–Graphene Hydrogels

et al. 2021

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Biomaterials capable of transmitting signals over longer distances than those in rigid electronics can open new opportunities for humanity by mimicking the way tissues propagate information. For seamless mirroring of the human body, they also have to display conformability to its curvilinear architecture, as well as, reproducing native‐like mechanical and electrical properties combined with the ability to self‐heal on demand like native organs and tissues. Along these lines, a multifunctional composite is developed by mixing silk fibroin and reduced graphene oxide. The material is coined “CareGum” and capitalizes on a phenolic glue to facilitate sacrificial and hierarchical hydrogen bonds. The hierarchal bonding scheme gives rise to high mechanical toughness, record‐breaking elongation capacity of ≈25 000%, excellent conformability to arbitrary and complex surfaces, 3D printability, a tenfold increase in electrical conductivity, and a fourfold increase in Young's modulus compared to its pristine counterpart. By taking advantage of these unique properties, a durable and self‐healing bionic glove is developed for hand gesture sensing and sign translation. Indeed, CareGum is a new advanced material with promising applications in fields like cyborganics, bionics, soft robotics, human–machine interfaces, 3D‐printed electronics, and flexible bioelectronics.

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Section: Introductionmentioning

confidence: 99%

The Manufacture of Unbreakable Bionics via Multifunctional and Self‐Healing Silk–Graphene Hydrogels

et al. 2021

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“…In the best case, the degradation should be identical to the rate at which new tissue is formed by the cells. When working with B. mori silk fibroin materials, the degradation behavior can be tuned by the choice of fabrication strategy, for example, the use of different solvents during processing, or by the incorporation of enzyme-sensitive peptides or degradation-promoting supplements [ 81 ]. To mimic the complexity of natural tissue, engineering approaches are destined to use multiple materials, fabricated in various morphology, together with cells and biologicals to carry out specific functions.…”

Section: Silkmentioning

confidence: 99%

Silk-Based Materials for Hard Tissue Engineering

2021

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Hard tissues, e.g., bone, are mechanically stiff and, most typically, mineralized. To design scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues must align with those found in the natural tissue. Combining these aspects poses challenges for material and construct design. Silk-based materials are promising for bone tissue regeneration as they fulfill several of such necessary requirements, and they are non-toxic and biodegradable. They can be processed into a variety of morphologies such as hydrogels, particles and fibers and can be mineralized. Therefore, silk-based materials are versatile candidates for biomedical applications in the field of hard tissue engineering. This review summarizes silk-based approaches for mineralized tissue replacements, and how to find the balance between sufficient material stiffness upon mineralization and cell survival upon attachment as well as nutrient supply.

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“…The important biological features of silk fibroin from Bombyx mori have marked this protein as a good biomaterial for tissue repair and regeneration [ 73 ]. Many studies have been performed by several research groups aiming at exploring the great potential of silk fibroin, alone or in combination with other materials and through different processing methods, in order to define advanced approaches for wound healing and tissue engineering applications.…”

Section: Recent Advances On the Development Of Silk Fibroin-based mentioning

confidence: 99%

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Pollini

Paladini

2020

Materials

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Nature is an incredible source of inspiration for scientific research due to the multiple examples of sophisticated structures and architectures which have evolved for billions of years in different environments. Numerous biomaterials have evolved toward high level functions and performances, which can be exploited for designing novel biomedical devices. Naturally derived biopolymers, in particular, offer a wide range of chances to design appropriate substrates for tissue regeneration and wound healing applications. Wound management still represents a challenging field which requires continuous efforts in scientific research for definition of novel approaches to facilitate and promote wound healing and tissue regeneration, particularly where the conventional therapies fail. Moreover, big concerns associated to the risk of wound infections and antibiotic resistance have stimulated the scientific research toward the definition of products with simultaneous regenerative and antimicrobial properties. Among the bioinspired materials for wound healing, this review focuses attention on a protein derived from the silkworm cocoon, namely silk fibroin, which is characterized by incredible biological features and wound healing capability. As demonstrated by the increasing number of publications, today fibroin has received great attention for providing valuable options for fabrication of biomedical devices and products for tissue engineering. In combination with antimicrobial agents, particularly with silver nanoparticles, fibroin also allows the development of products with improved wound healing and antibacterial properties. This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.

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Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications

Cited by 54 publications

References 153 publications

The Manufacture of Unbreakable Bionics via Multifunctional and Self‐Healing Silk–Graphene Hydrogels

The Manufacture of Unbreakable Bionics via Multifunctional and Self‐Healing Silk–Graphene Hydrogels

Silk-Based Materials for Hard Tissue Engineering

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

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