Strategies for Tissue Engineering Vascularized Cardiac Patches to Treat Myocardial Infarctions

Morrissette‐McAlmon, Justin; Hawthorne, Robert N.; Snyder, S. H.; Grayson, Warren L.

doi:10.1007/978-3-319-99319-5_6

Cited by 1 publication

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References 140 publications

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“…[137,143] Classical bulk hydrogels can inhibit cell-cell connections between encapsulated cardiomyocytes. [137,150] Further, key features of the cardiac ECM including its fibrous microstructure, multiscale laminar architecture, geometric constraints, mechanical strength, anisotropy, and electroconductivity are difficult or impossible to recreate using classical bulk hydrogels alone. More advanced biomaterial systems are needed to www.advanced-bio.com recreate the multiscale complexity of the native cardiac tissue.…”

Section: Hydrogel Composites For Heart Muscle Tissue Engineering: Ecm...mentioning

confidence: 99%

Advancing Engineered Heart Muscle Tissue Complexity with Hydrogel Composites

Dickerson

2022

Advanced Biology

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A heart attack results in the permanent loss of heart muscle and can lead to heart disease, which kills more than 7 million people worldwide each year. To date, outside of heart transplantation, current clinical treatments cannot regenerate lost heart muscle or restore full function to the damaged heart. There is a critical need to create engineered heart tissues with structural complexity and functional capacity needed to replace damaged heart muscle. The inextricable link between structure and function suggests that hydrogel composites hold tremendous promise as a biomaterial‐guided strategy to advance heart muscle tissue engineering. Such composites provide biophysical cues and functionality as a provisional extracellular matrix that hydrogels cannot on their own. This review describes the latest advances in the characterization of these biomaterial systems and using them for heart muscle tissue engineering. The review integrates results across the field to provide new insights on critical features within hydrogel composites and perspectives on the next steps to harnessing these promising biomaterials to faithfully reproduce the complex structure and function of native heart muscle.

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Section: Hydrogel Composites For Heart Muscle Tissue Engineering: Ecm...mentioning

confidence: 99%

Advancing Engineered Heart Muscle Tissue Complexity with Hydrogel Composites

Dickerson

2022

Advanced Biology

View full text Add to dashboard Cite

show abstract

Strategies for Tissue Engineering Vascularized Cardiac Patches to Treat Myocardial Infarctions

Cited by 1 publication

References 140 publications

Advancing Engineered Heart Muscle Tissue Complexity with Hydrogel Composites

Advancing Engineered Heart Muscle Tissue Complexity with Hydrogel Composites

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