Strategies for the eradication of intracellular bacterial pathogens

Chen, Yingying; Jiang, Yunjiang; Xue, Tianrui; Cheng, Jianjun

doi:10.1039/d3bm01498c

Biomater. Sci.

2024

DOI: 10.1039/d3bm01498c

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Strategies for the eradication of intracellular bacterial pathogens

Yingying Chen,

Yunjiang Jiang,

Tianrui Xue

et al.

Abstract: Intracellular pathogens affect a significant portion of world population and cause millions of deaths each year. They can invade and survive inside of host cells and are extremely resistant to...

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Cited by 1 publication

References 174 publications

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Antibiotic-Loaded Nano-Sized Delivery Systems: An Insight into Gentamicin and Vancomycin

Pisani,

Tufail,

Rosalia

et al. 2024

JFB

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The fight against infectious disease has remained an ever-evolving challenge in the landscape of healthcare. The ability of pathogens to develop resistance against conventional drug treatments has decreased the effectiveness of therapeutic interventions, and antibiotic resistance is recognized as one of the main challenges of our time. The goal of this systematic review paper is to provide insight into the research papers published on innovative nanosized drug delivery systems (DDSs) based on gentamycin and vancomycin and to discuss the opportunity of their repurposing through nano DDS formulations. These two antibiotics are selected because (i) gentamicin is the first-line drug used to treat suspected or confirmed infections caused by Gram-negative bacterial infections and (ii) vancomycin is used to treat serious Gram-positive bacterial infections. Moreover, both antibiotics have severe adverse effects, and one of the purposes of their formulation as nanosized DDSs is to overcome them. The review paper includes an introduction focusing on the challenges of infectious diseases and traditional therapeutic treatments, a brief description of the chemical and pharmacological properties of gentamicin and vancomycin, case studies from the literature on innovative nanosized DDSs as carriers of the two antibiotic drugs, and a discussion of the results found in the literature.

show abstract

Antibiotic-Loaded Nano-Sized Delivery Systems: An Insight into Gentamicin and Vancomycin

Pisani,

Tufail,

Rosalia

et al. 2024

JFB

View full text Add to dashboard Cite

show abstract

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Strategies for the eradication of intracellular bacterial pathogens

Abstract: Intracellular pathogens affect a significant portion of world population and cause millions of deaths each year. They can invade and survive inside of host cells and are extremely resistant to...

Cited by 1 publication

References 174 publications

Antibiotic-Loaded Nano-Sized Delivery Systems: An Insight into Gentamicin and Vancomycin

Antibiotic-Loaded Nano-Sized Delivery Systems: An Insight into Gentamicin and Vancomycin

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