Strategies for the Development of Asymmetric and Non‐Directed Petasis Reactions
Kevin J. Gonzalez,
Chloe Cerione,
Brian M. Stoltz
Abstract:The Petasis reaction is a multicomponent reaction of aldehydes, amines and organoboron reagents and is a useful method for the construction of substituted amines. Despite the significant advancement of the Petasis reaction since its invention in 1993, strategies for asymmetric and non‐directed Petasis reactions remain limited. To date, there are very few catalytic asymmetric Petasis reactions and almost all asymmetric reports employ a chiral auxiliary. Likewise, the aldehyde component often requires a directin… Show more
This review summarizes recent advances in alkynyl trifluoroborate chemistry, emphasizing their unique reactivity and stability in organic synthesis and biological applications under transition metal catalyst-free conditions.
This review summarizes recent advances in alkynyl trifluoroborate chemistry, emphasizing their unique reactivity and stability in organic synthesis and biological applications under transition metal catalyst-free conditions.
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