Strategies for sustained release of heparin: A review

Yang, Xuewen; Wang, Qiuxiang; Zhang, Aiwen; Shao, Xinyao; Liu, Tianqing; Tang, Bo; Fang, Guihua

doi:10.1016/j.carbpol.2022.119793

Cited by 27 publications

(7 citation statements)

References 104 publications

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“…The adsorption on the surface of the carbonaceous material occurs through hydrophobic interactions facilitated by heparin contributing to the stabilization of the nanoparticles. 47,48 The histogram (Fig. 3F) shows the average diameter of Gr-AuNPs-Hep (15.2 ± 3.0 nm) in the presence of graphene.…”

Section: Resultsmentioning

confidence: 99%

Heparin-stabilized gold nanoparticles embedded in graphene for the electrochemical determination of esculetin

da Silva,

Baumgarten,

Dreyer

et al. 2024

Anal. Methods

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Section: Resultsmentioning

confidence: 99%

Heparin-stabilized gold nanoparticles embedded in graphene for the electrochemical determination of esculetin

da Silva,

Baumgarten,

Dreyer

et al. 2024

Anal. Methods

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“…( Kevin, 2015 ). Furthermore, the half-life of heparin is less than 1 h in circulation ( Yang et al, 2022 ). Thus, maintaining localized concentration and homodisperse of heparin at the target site for long time is essential for implant revascularization.…”

Section: Resultsmentioning

confidence: 99%

“…After more than 40 years of continuous development, the immobilization technology of heparin is showing more and more improvement in medical field. Although heparin presented obvious anti-coagulation and anti-hyperplasia effects, the existing immobilization methods, such as physical blending, ionic bonding, and covalent bonding by solution blending or solution grafting, cannot solve the problems of fast release, easy inactivation, and structural changes of heparin, which may be due to its very short half-life and easy dissolution in water rather than in organic solvents ( Serrone et al, 2013 ; Kevin, 2015 ; Yang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Nanofibers with homogeneous heparin distribution and protracted release profile for vascular tissue engineering

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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In clinic, controlling acute coagulation after small-diameter vessel grafts transplantation is considered a primary problem. The combination of heparin with high anticoagulant efficiency and polyurethane fiber with good compliance is a good choice for vascular materials. However, blending water-soluble heparin with fat-soluble poly (ester-ether-urethane) urea elastomer (PEEUU) uniformly and preparing nanofibers tubular grafts with uniform morphology is a huge challenge. In this research, we have compounded PEEUU with optimized constant concentration of heparin by homogeneous emulsion blending, then spun into the hybrid PEEUU/heparin nanofibers tubular graft (H-PHNF) for replacing rats’ abdominal aorta in situ for comprehensive performance evaluation. The in vitro results demonstrated that H-PHNF was of uniform microstructure, moderate wettability, matched mechanical properties, reliable cytocompatibility, and strongest ability to promote endothelial growth. Replacement of resected abdominal artery with the H-PHNF in rat showed that the graft was capable of homogeneous hybrid heparin and significantly promoted the stabilization of vascular smooth muscle cells (VSMCs) as well as stabilizing the blood microenvironment. This research demonstrates the H-PHNF with substantial patency, indicating their potential for vascular tissue engineering.

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“…Heparin is another interesting natural polysaccharide with pronounced hydrophilicity due to the numerous polar functional groups (e.g., OH, CO 2 − , NHSO 3 − , OSO 3 − ) around the glycosaminoglycan polymer backbone that serve as H-bond acceptors and donors. 42 Heparin is also well-known for its anticoagulant properties and thus plays an important role in biomedical science. In the context of drug nano-delivery, heparin can also serve as a useful component of the overall molecular architecture.…”

Section: Polysaccharidesmentioning

confidence: 99%