Strategies for studying in vivo biochemical formation pathways and multilevel distributions of sulfanilamide metabolites in food (2012–2022)

Jia, Wei; Zhang, Min; Zhu, Jiying; Shi, Lin

doi:10.1016/j.foodchem.2022.133039

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…Although SDM and OMP help in reducing the incidence of infectious diseases, their use may lead to residues in food products, posing potential health risks to consumers such as allergic reactions, carcinogenesis, or induction of the development of pathogenic bacteria-resistant strains [5,19,20]. Thus, the Maximum Residue Limits (MRLs) in foodstuffs of animal origin have been established for these and other veterinary drug residues [19,21]. The MRL adopted for SDM and OMP in fish fillets (muscle plus skin in natural proportions) is 100 µg kg −1 [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Residue Depletion Profile and Estimation of Withdrawal Period for Sulfadimethoxine and Ormetoprim in Edible Tissues of Nile Tilapia (Oreochromis sp.) on Medicated Feed

Freitas

Júnior

Damaceno

et al. 2023

Animals

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Sulfadimethoxine (SDM) and ormetoprim (OMP) are antimicrobials used in combination to treat bacterial infections in fish farming. The use of this drug combination is not yet regulated in some countries, such as Brazil. Due to the lack of regulated drugs for aquaculture in Brazil, this study investigated the residue depletion profile of SDM and OMP in Nile tilapia (Oreochromis sp.) after oral administration. Fish were treated with medicated feed containing a 5:1 ratio of SDM:OMP at the dose of 50 mg kg BW−1 for five consecutive days with an average water temperature of 28 °C. The drugs were incorporated into the feed by using a gelatin coating process which promoted homogeneity in drug concentration and prevented the drug leaching into the water during medication. The SDM and OMP determination in fish fillets (muscle plus skin in natural proportions) was performed using the QuEChERS approach followed by LC-MS/MS quantification. The analytical method was validated according to Brazilian and selected international guidelines. A withdrawal period of 9 days (or 252 °C days) was estimated for the sum of SDM and OMP residues at concentration levels below the maximum residue level of 100 µg kg−1.

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Section: Introductionmentioning

confidence: 99%

Residue Depletion Profile and Estimation of Withdrawal Period for Sulfadimethoxine and Ormetoprim in Edible Tissues of Nile Tilapia (Oreochromis sp.) on Medicated Feed

Freitas

Júnior

Damaceno

et al. 2023

Animals

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“…With the development of technologies based on nuclear magnetic resonance, mass spectrometry, or chromatography, a great deal of information about metabolites and multivariate statistical tools have been collected and developed ( Jia et al, 2022 ). A rapid automatic analysis and identification system combined with simple operating methods offered new opportunities to globally analyze all small-molecule metabolites present within fungi in a particular physiological state ( Gika et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima

Zhang²,

Su³

et al. 2022

Front. Pharmacol.

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Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life. Marsdenia tenacissima is an antitumor of Chinese medicine. However, Marsdenia tenacissima has low bioavailability in the human body and most of its main active substances are aglycones, such as Tenacigenin A, Tenacigenin B. This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of Ganoderma lucidum. Non-targeted metabolomics analysis was carried out on the fermentation products after the optimization process. A total of 249 differential metabolites were detected, and the content of saponins increased from 0.1% to 0.41% and most of them were tenacigenin. Furthermore, the biotransformation of C21 steroidal glycosides in Marsdenia tenacissima was the central reaction in this fermentation process. Pharmacodynamics resewed that the anticancer effect of Marsdenia tenacissima was significantly enhanced after fermentation, mainly through inhibiting the growth and apoptosis of cancer cells.

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Flower-like calix[6]arene-based covalent organic framework for membrane extraction of sulfonamides in animal-derived food through host-guest interaction prior to determination with ultra-high performance liquid chromatography-tandem mass spectrometry

Lin,

Xie,

et al. 2024

Journal of Chromatography A

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Strategies for studying in vivo biochemical formation pathways and multilevel distributions of sulfanilamide metabolites in food (2012–2022)

Cited by 5 publications

References 69 publications

Residue Depletion Profile and Estimation of Withdrawal Period for Sulfadimethoxine and Ormetoprim in Edible Tissues of Nile Tilapia (Oreochromis sp.) on Medicated Feed

Residue Depletion Profile and Estimation of Withdrawal Period for Sulfadimethoxine and Ormetoprim in Edible Tissues of Nile Tilapia (Oreochromis sp.) on Medicated Feed

Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima

Flower-like calix[6]arene-based covalent organic framework for membrane extraction of sulfonamides in animal-derived food through host-guest interaction prior to determination with ultra-high performance liquid chromatography-tandem mass spectrometry

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