Strategies for Rhythm Control in Atrial Fibrillation

Narayanan, Kumar

doi:10.1177/2632463620936018

Cited by 3 publications

(4 citation statements)

References 119 publications

(135 reference statements)

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“…This gainoffunction mutation causes a reduction in APD length [9]. Atrial fibrillation has also been related to a mutation in the KCNH2 gene that results in a lack of function [11].…”

Section: B Mutations Involving the Rapidly Repolarizing Potassium Cur...mentioning

confidence: 99%

“…Current recommendations prescribe beta-blockers strongly for people with HFrEF (class I, level of evidence A) [10]. Rate control is the use of negatively chronotropic medicines or electrophysiological/surgical techniques to lower the often fast ventricular rate in atrial fibrillation patients [11].…”

Section: A Rate Controlmentioning

confidence: 99%

“…A strategy of rate control alone may not be enough to treat atrial fibrillation-mediated cardiomyopathy or chronic symptoms [11]. Rhythm regulation, whether done pharmacologically, with electrical cardioversion, or catheter ablation, has been demonstrated to improve LV dysfunction and have a positive influence on survival and quality of life [12].…”

Section: B Rhythm Controlmentioning

confidence: 99%

“…Rhythm regulation, whether done pharmacologically, with electrical cardioversion, or catheter ablation, has been demonstrated to improve LV dysfunction and have a positive influence on survival and quality of life [12]. The goal of the rate control technique is to solely lower ventricular rates brought on by atrial fibrillation [11]. The CAFÉ-II trial found evidence that rhythm control is associated with better quality of life (p=0.020) and LV function (p=0.014) in heart failure patients, despite the restricted number of participants [12].…”

Section: B Rhythm Controlmentioning

confidence: 99%

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Recent Biotechnological Approach to Genetically Determined Atrial Fibrillation

Arad¹,

Haim²,

Guy³

et al. 2022

Proceedings of the 12th International Conference on “Electronics, Communications and Computing"

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The most prevalent persistent arrhythmia in cardiology is atrial fibrillation. Former atrial fibrillation which appears without any underlying reason was called „lone atrial fibrillation“. Due to new biotechnological methods in electrophysiology, like mapping, unusual conducting mechanisms were stabilized. Due to new biotechnological methods of DNA analysis recently the reason is detected. This is a genetically determined atrial fibrillation. The aim of this study is to analyse what are the most common mutations which lead to atrial fibrillation. Material and methods. This is a systematic review study. The sources of information which were analysed are mostly from google scholar and web of science. From 2000 sources, several sources were filtered out by the keywords and remained 14 sources on which is based this review study. Results. More than 70 genes are recently detected which lead to atrial fibrillations. Majority of them are mutations of the genes which encode the transport proteins of the heart’s conductive system. The most common mutations that lead to genetically determined atrial fibrillation occure in KCNQ1, KCNA5 and 6q14–16. Conclusions. Before starting treatment of lone atrial fibrillation, a genetical test should be done in order to stabilize the type of the underlying mutation. This is a tactical step in taking the decision on treatment strategy by antiarrhytmic drugs or ablation. So ablatogenoics is the best solution for patients with genetically determined atrial fibrillation.

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“…This gainoffunction mutation causes a reduction in APD length [9]. Atrial fibrillation has also been related to a mutation in the KCNH2 gene that results in a lack of function [11].…”

Section: B Mutations Involving the Rapidly Repolarizing Potassium Cur...mentioning

confidence: 99%

Section: A Rate Controlmentioning

confidence: 99%

Section: B Rhythm Controlmentioning

confidence: 99%

Section: B Rhythm Controlmentioning

confidence: 99%

See 2 more Smart Citations

Recent Biotechnological Approach to Genetically Determined Atrial Fibrillation

Arad¹,

Haim²,

Guy³

et al. 2022

Proceedings of the 12th International Conference on “Electronics, Communications and Computing"

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The efficacy of synchronized direct current shock in reverting long standing persistent atrial fibrillation in to sinus rhythm. What help to achieve high success rate?

Alhamdi¹,

Ali²

2021

JFacMedBagdad

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Background: Atrial fibrillation is the most frequent cardiac arrhythmia encountered in general medicine and cardiology practice. Synchronized direct current shock is a known safe and effective procedure to revert long standing persistent atrial fibrillation into sinus rhythm. Patients and Methods: Patients with long-standing atrial fibrillation who were seen at the author’s private clinic and Al-Hassani Heart Center in Sulaimanya from April 2018 to December 2020 were chosen for rhythm control subjected to synchronized direct current cardioversion under heavy sedation applying a modified anterolateral paddles position with 200J and 300J successively according to the reversion dose required. Objectives: The Objective of current study was to assess the efficacy of synchronized direct current shock in reverting long-standing persistent atrial fibrillation into sinus rhythm and recognizing factors that help in achieving high success rate. Results: In this case series study 61 patients were included thirty-one males 30 females The success rate was 89%. Even patients with atrial fibrillation duration more than 2 years showed a success rate of 84%. The recurrence rate of atrial fibrillation was 30% within a follow up period of one month to 2 years. The modified paddles position has helped in achieving high reversion rate where success increased from 62% to 85% and failure rate decreased from 38% to 15%. The shock dose needed for reversion ranged from 200J to 300 J. There was no correlation between the needed dose for reversion and body weight where patients with body weight of 71-80kg, more than 80% reverted with 200J. Pre shock antiarrhythmic drugs did not facilitate the conversion, the reversion rate in patients with or without antiarrhythmic drugs were 85% and 82% successively. No per procedure complications were seen. Conclusion: Electrical cardioversion of atrial fibrillation with modified paddles position is a safe, effective and smooth procedure with significantly high success rate and very low incidence of complications even with very long-standing atrial fibrillation.

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Recent Advances in the Management of Non-rheumatic Atrial Fibrillation: A Comprehensive Review

Kadam,

Kotak,

Khurana

et al. 2024

Cureus

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Atrial fibrillation (AF) is a prevalent cardiac arrhythmia characterized by irregular atrial electrical activity, posing significant challenges to patient management and healthcare systems worldwide. Non-rheumatic AF, distinct from AF due to rheumatic heart disease, encompasses a spectrum of etiologies, including hypertension, coronary artery disease, and structural heart abnormalities. This review examines the latest advancements in managing non-rheumatic AF, encompassing diagnostic approaches, pharmacological therapies, and innovative non-pharmacological interventions. Diagnostic strategies ranging from traditional electrocardiography to advanced imaging modalities are explored alongside emerging biomarkers and wearable technologies facilitating early detection and management. Pharmacological management options, including novel anticoagulants and rhythm control agents, are evaluated in light of current guidelines and recent clinical trials. Non-pharmacological interventions, such as catheter ablation and device-based therapies, are discussed regarding their evolving techniques and outcomes. Special considerations for diverse patient populations, including elderly individuals and athletes, are addressed, emphasizing personalized approaches to optimize therapeutic outcomes. The review concludes with insights into future directions for AF management, highlighting promising avenues in gene therapy, regenerative medicine, and precision medicine approaches. By synthesizing recent research findings and clinical innovations, this review provides a comprehensive overview of the dynamic landscape of non-rheumatic AF management, offering insights for clinicians, researchers, and healthcare stakeholders.

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Strategies for Rhythm Control in Atrial Fibrillation

Cited by 3 publications

References 119 publications

Recent Biotechnological Approach to Genetically Determined Atrial Fibrillation

Recent Biotechnological Approach to Genetically Determined Atrial Fibrillation

The efficacy of synchronized direct current shock in reverting long standing persistent atrial fibrillation in to sinus rhythm. What help to achieve high success rate?

Recent Advances in the Management of Non-rheumatic Atrial Fibrillation: A Comprehensive Review

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