Strategies for Improved Production of Epstein-Barr Virus

Davies, Adam; Huddelston, J; Evans, Fred J.; Rickinson, Alan B.; Emery, A. N.

doi:10.1016/b978-0-7506-1103-9.50125-6

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Induction Of Lytic Ebv Infection1

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2003

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“…Calcium-induced activation of MEF2D (mediated by calcineurin) and CREB (mediated by CaMKIV/GR) appears to be important for BZLF1 promoter activation following ligation of the B-cell receptor Liu et al, 1997). The inducing effect of phorbol esters is mediated through protein kinase C (PKC) (Davies et al, 1991), and also primarily requires the ZI and ZII binding motifs in the BZLF1 promoter , although the intermediary factors are not well defined. However, PKC activation is not required for induction of lytic EBV by certain stimuli (Gradoville et al, 2002).…”

Section: Induction Of Lytic Ebv Infectionmentioning

confidence: 99%