Strategies for Functionalization of Metallic Surfaces with Bioactive Peptides: a Mini Review

Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

“…20 Additionally, peptides can be incorporated into pre-formed functionalised SAMs, for instance, rendering antifouling surfaces 21 and functionalised surgical implants. 22 (ii) Control over secondary structure. Peptides confer different flexibility levels to SAMs surfaces due to their ability to adopt secondary structures (including 3 10 -and a-helices, as well as b-sheets and b-hairpins, among others).…”

“…Apart from Au, peptide-based SAMs have also been prepared on other inorganic substrates, including metals such as Ti, Co, Cr, and stainless steels, 22 metal oxides via phosphonic acids (R-PO 3 , R = alkyl chain), 40 as well as other substrates such as quartz, 35,41 silicon, glass, 42 and modified glassy carbon electrodes (GCE), using different organosilane species (R-Si-X 3 , R 2 -Si-X 2 or R 3 -Si-X, R = alkyl chain, X = Cl or alkoxy group) 43 and other chemical surface reactions, 17,44,45 as detailed in Sections 2.2.5 and 2.2.6.…”

“…20 Additionally, peptides can be incorporated into pre-formed functionalised SAMs, for instance, rendering antifouling surfaces 21 and functionalised surgical implants. 22…”

Functional anti-bone tumor biomaterial scaffold: construction and application

“…35 (4) Electrochemical deposition: bioactive molecules, such as peptides and proteins, are deposited on the surface of biomaterial scaffolds using an applied voltage. 36 This method requires high physical and chemical properties of the material surface, as well as the preparation of electrodes and control of the conditions of the electrode reaction. 36 (5) 3D printing: the carrierization of biologically active molecules is achieved by altering the surface structure or building pores of biomaterial scaffolds through 3D printing techniques.…”

“…36 This method requires high physical and chemical properties of the material surface, as well as the preparation of electrodes and control of the conditions of the electrode reaction. 36 (5) 3D printing: the carrierization of biologically active molecules is achieved by altering the surface structure or building pores of biomaterial scaffolds through 3D printing techniques. 37 This approach requires sophisticated 3D printing techniques and equipment, but allows for highly and porosity personalized biomaterial scaffolds.…”