Strategies for Expanding Donors Pool in Heart Transplantation

Jacob, Samuel; Garg, Pankaj; Wadiwala, Ishaq; Yazji, John H.; Alomari, Mohammad.; Alamouti-Fard, Emad; Hussain, Md Walid Akram; Pham, Si M.

doi:10.31083/j.rcm2308285

Cited by 2 publications

(2 citation statements)

References 111 publications

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“…The number of heart transplants performed in Korea has climbed to 1,513 cases between 1992 and 2017, with the majority of transplants in Asia being carried out in Taiwan and Korea [ 60 ]. Strategies to expand the donor pool include the use of ECDs, improved organ preservation techniques, the utilization of repairable hearts, and the use of DCD donors [ 61 , 62 ].…”

Section: Organ Care Systemmentioning

confidence: 99%

Ex vivo lung perfusion and the Organ Care System: a review

Attawar,

et al. 2024

Clin Transplant Res

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With the increasing prevalence of heart failure and end-stage lung disease, there is a sustained interest in expanding the donor pool to alleviate the thoracic organ shortage crisis. Efforts to extend the standard donor criteria and to include donation after circulatory death have been made to increase the availability of suitable organs. Studies have demonstrated that outcomes with extended-criteria donors are comparable to those with standard-criteria donors. Another promising approach to augment the donor pool is the improvement of organ preservation techniques. Both ex vivo lung perfusion (EVLP) for the lungs and the Organ Care System (OCS, TransMedics) for the heart have shown encouraging results in preserving organs and extending ischemia time through the application of normothermic regional perfusion. EVLP has been effective in improving marginal or borderline lungs by preserving and reconditioning them. The use of OCS is associated with excellent short-term outcomes for cardiac allografts and has improved utilization rates of hearts from extended-criteria donors. While both EVLP and OCS have successfully transitioned from research to clinical practice, the costs associated with commercially available systems and consumables must be considered. The ex vivo perfusion platform, which includes both EVLP and OCS, holds the potential for diverse and innovative therapies, thereby transforming the landscape of thoracic organ transplantation.

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Section: Organ Care Systemmentioning

confidence: 99%

Ex vivo lung perfusion and the Organ Care System: a review

Attawar,

et al. 2024

Clin Transplant Res

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“…Tissue engineering is a modern technique that can overcome several current problems. [ 45 ] Tissue engineering means repairing and replacing the damaged tissues in the body, which requires a combination of certain cells, growth factors, and porous scaffolds. Tissue engineering combines living cells with biodegradable organic or synthetic scaffolds to mimic the 3D living structures that are structurally, mechanically, and functionally equivalent to or superior to the tissue they are envisioned to replace.…”

Section: Nanofibers Functionalization Techniquementioning

confidence: 99%

Smart Nanofibers: Synthesis, Properties, and Scopes in Future Advanced Technologies

Chamanehpour,

Thouti,

Rubahn

et al. 2023

Adv Materials Technologies

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Functional nanoengineering of nanofibrous materials is getting more important day by day due to an increased demand for smart nanomaterials in many industrial technologies. A simple synthesis and extraordinary features, e.g., high specific surface area, multi‐dimensional structure, small pores, self‐adjustment, flexibility, elasticity, etc., open a wide application range for smart nanofibers as important components in daily‐life appliances. These nanofibrous materials can potentially revolutionize medical, agriculture, food, energy, water, and wastewater treatment technologies due to their capacity to detect small changes (ppm and ppb levels) and simultaneously react to the involved environmental stimuli. In this work, a detailed overview of smart nanofibers in terms of their functionalities, fabrication strategies, and technological applications relevant to fulfilling society's sustainable development goals (SDGs) is provided. Various techniques for functionalizing the nanofibers are covered, along with their unique characteristics, which strengthen the portfolio of properties and thus new applications. Finally, the important usage of nanofibers in the environmental and human healthcare fields is briefly discussed, along with the potential applications in other future technologies. This work demonstrates the challenges and possibilities for smart nanofibers and their applications while simultaneously addressing a new era of multidisciplinary research toward the creation and new uses of smart nanofibers.

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Strategies for Expanding Donors Pool in Heart Transplantation

Cited by 2 publications

References 111 publications

Ex vivo lung perfusion and the Organ Care System: a review

Ex vivo lung perfusion and the Organ Care System: a review

Smart Nanofibers: Synthesis, Properties, and Scopes in Future Advanced Technologies

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