Strategies for endometrial screening in the Lynch syndrome population: a patient acceptability study

Elmasry, Karim; Davies, Anthony; Evans, D. Gareth; Seif, M; Reynolds, Karina

doi:10.1007/s10689-009-9259-3

Cited by 11 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as far as we know, there is no information about the degree of pain as well as the influence of pain scores on clinical decision-making during surveillance in women with LS. Only one study reported on patient acceptability of endometrial sampling in LS surveillance and the authors conclude that transvaginal ultrasonography is associated with less discomfort than hysteroscopy or endometrial sampling, and will therefore be the preferred test of choice for the majority [15]. There is no significant difference between the pain scores for hysteroscopy and endometrial sampling [15].…”

Section: Discussionmentioning

confidence: 99%

“…Only one study reported on patient acceptability of endometrial sampling in LS surveillance and the authors conclude that transvaginal ultrasonography is associated with less discomfort than hysteroscopy or endometrial sampling, and will therefore be the preferred test of choice for the majority [15]. There is no significant difference between the pain scores for hysteroscopy and endometrial sampling [15]. In studies reporting on preventive surgery in women with LS no information is given so far about the influence of pain during the surveillance visits in making the decision for preventive surgery [16, 17].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pain evaluation during gynaecological surveillance in women with Lynch syndrome

et al. 2016

View full text Add to dashboard Cite

To evaluate perceived pain during repetitive annual endometrial sampling at gynaecologic surveillance in asymptomatic women with Lynch syndrome (LS) over time and in addition to symptomatic women without LS, undergoing single endometrial sampling. In this prospective study, 52 women with LS or first degree relatives who underwent repetitive annual gynaecological surveillance including endometrial sampling of which 33 were evaluated twice or more and 50 symptomatic women without LS who had single endometrial sampling, were included. Pain intensity was registered with VAS scores. Differences in pain intensities between subsequent visits (in LS) and between the two groups were evaluated. The use of painkillers before endometrial sampling was registered. If women with LS decided for preventive surgery, the reason was recorded. The LS group reported a median VAS score of 5.0 (range 0–10) at the first surveillance (n = 52) and at the second visit (n = 24). Women who repeatedly underwent endometrial sampling more often used painkillers for this procedure. During the study period 7/52 (13 %) women with LS choose for preventive surgery, another 4/52 (8 %) refused further endometrial sampling. Painful endometrial sampling was mentioned as main reason to quit screening. The median VAS score of the 50 symptomatic women was 5.0 (range 1–9). Endometrial sampling, irrespective of indication, is a painful procedure, with a median VAS score of 5.0. During subsequent procedures in women with LS, the median pain score does not aggravate although one in five women chose an alternative for endometrial sampling.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pain evaluation during gynaecological surveillance in women with Lynch syndrome

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Elmasry et al 58 assessed the patient acceptability of the available screening modalities. Transvaginal ultrasound was associated with less discomfort than hysteroscopy or Pipelle biopsy.…”

Section: Question Nomentioning

confidence: 99%

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

Vasen

Blanco

Aktán-Collán

et al. 2013

Gut

633

565

View full text Add to dashboard Cite

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.

show abstract

“…A recent study evaluating acceptability of screening, found no significant difference in pain scores between either hysteroscopy or endometrial sampling. [30] The efficacy and patient acceptability of OHES is similar to the in-patient procedure and the former is more cost-effective. [31,32] Preliminary data suggest that hysteroscopy-based endometrial screening in LS does not appear to be associated with any psychological morbidity.…”

Section: Discussionmentioning

confidence: 99%