Strategies for Drug Encapsulation and Controlled Delivery Based on Vapor‐Phase Deposited Thin Films

Perrotta, Alberto; Werzer, Oliver; Coclite, Anna Maria

doi:10.1002/adem.201700639

Cited by 34 publications

(47 citation statements)

References 142 publications

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“…Stimuli-responsive hydrogels can be successfully deposited by initiated chemical vapor deposition (iCVD): a low-energy, one step, film forming process that can be advantageously used to embed a bio-active molecule in a polymer encapsulant layer. This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the integrity of the active compound, and retention of the monomer structure in the encapsulating coating [17,18].…”

Section: Introductionmentioning

confidence: 99%

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

et al. 2020

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A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

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Section: Introductionmentioning

confidence: 99%

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

et al. 2020

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“…In such systems, the polymeric coating can serve multiple purposes at once. For instance, stabilization of the solid state of a drug may be achieved by polymeric encapsulation, which limits the environmental exposure 1. At the same time, these coatings can be beneficial for several therapies as they enable controlled drug release and minimize severe side effects due to burst release 2…”

Section: Introductionmentioning

confidence: 99%

Drug release from thin films encapsulated by a temperature-responsive hydrogel

et al. 2019

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“…Vapor phase deposition method [78,79] is a recently developed coating technology for pharmaceutical solid dosages. It is capable of synthesizing polymer coating films with an engineered surface, functionalities, and topography with satisfactory uniformity.…”

Section: Coating Processmentioning

confidence: 99%

An Update of Moisture Barrier Coating for Drug Delivery

Yang

Feng

et al. 2019

Pharmaceutics

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Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hydrolytic degradation during the manufacturing process and storage. Coating formulation design and process control are the two most commonly used strategies to reduce water vapor permeability to achieve the moisture barrier function. The principles of formulation development include designing a coating formulation with non-hygroscopic/low water activity excipients, and formulating the film-forming polymers with the least amount of inherent moisture. The coating process involves spraying organic or aqueous coating solutions made of natural or synthetic polymers onto the surface of the dosage cores in a drum or a fluid bed coater. However, the aqueous coating process needs to be carefully controlled to prevent hydrolytic degradation of the drug due to the presence of water during the coating process. Recently, different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film. Those strategies include newly designed coating formulations containing polymers with optimized functionality of moisture barrier, and newly developed dry coating processes that eliminate the usage of organic solvent and water, and could potentially replace the current solvent and aqueous coatings. This review aims to summarize the recent advances and updates in moisture barrier coatings.

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Strategies for Drug Encapsulation and Controlled Delivery Based on Vapor‐Phase Deposited Thin Films

Cited by 34 publications

References 142 publications

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Drug release from thin films encapsulated by a temperature-responsive hydrogel

An Update of Moisture Barrier Coating for Drug Delivery

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