Strategies for chiral separation: from racemate to enantiomer

Abstract

Chiral separation has already become a crucial topic for effectively utilizing superfluous racemates synthesized by chemical means and satisfying the growing requirements for producing enantiopure chiral compounds. However, the remarkably...

Chirality-induced supramolecular nanodishes: enantioselectivity and energy transfer

“…It is manifested in various life activities as it is prevalent throughout the structural level of molecules, supramolecules, and macroscopic substances. Recently, functional materials with fine chiral nanostructures have been developed and have exhibited excellent performance in the fields of asymmetric synthesis, 1–4 enantioselective sensing, 5–9 and chiral electronics. 10–14 Therefore, the aggregation of asymmetric nanostructures has become an important issue in the manufacturing of chiral functional materials.…”

The Same but Not the Same: The Case of (S)-Naproxen/cis-1-Amino-2-indanol Chiral Resolution via Diastereomeric Salt Formation

“…10−12 Numerous methods for racemic separation based on chiral resolution are available (e.g., kinetic resolution, chromatographic resolution, membrane separation, and crystallization), each with its own set of pros and cons. 15 An economic, common, and easy-to-scale-up method harnesses differences in solid-state and solubility properties of diastereomeric salt pairs, which lead to preferential precipitation of the least soluble one. Diastereomeric salts are formed by the reaction of the racemic mixture with an enantiomerically pure resolving agent in adequate conditions (solvent, temperature, crystallization time, etc.).…”

“…Chirality has in pharmaceutical companies a huge relevance , that has led pharmaceutical companies to develop, whenever possible, new drugs as single enantiomers, − driven also by advances in asymmetric synthesis and large-scale racemic separation tools. Quite recently, several APIs, previously marketed as racemic mixtures, have been replaced by the corresponding eutomer, a process named “chiral switching”, with the potential advantages of enhancing potency, selectivity, and safety of the therapy as well as lowering patient drug dosage exposure. − Numerous methods for racemic separation based on chiral resolution are available (e.g., kinetic resolution, chromatographic resolution, membrane separation, and crystallization), each with its own set of pros and cons …”

Improvement of the enantioselectivities of Mandyphos‐Pd complexes by introducing groups with different steric and electronic properties

“…Therefore, numerous efforts have been made to find and develop new and efficient chiral extractants over the years. [4][5][6][7][8][9] Cyclodextrins, 10 tartaric acids, [11][12][13] crown ethers 14,15 and diphosphine-metal complexes [16][17][18][19][20][21] are the most frequently used chiral extractants in ELLE. Among them, diphosphine-metal complexes have attracted much attention because of their high separation efficiencies and good versatility.…”

“…Chiral extractants play an important role in ELLE, conferring R , S ‐enantiomers with different distribution coefficients in extraction systems. Therefore, numerous efforts have been made to find and develop new and efficient chiral extractants over the years 4‐9 . Cyclodextrins, 10 tartaric acids, 11‐13 crown ethers 14,15 and diphosphine‐metal complexes 16‐21 are the most frequently used chiral extractants in ELLE.…”