Strategies for applying probiotics in the antibiotic management of <i>Clostridioides difficile</i> infection

Yang, Jingpeng; Meng, Lingtong; Li, Yanan; Huang, He

doi:10.1039/d3fo02110f

Cited by 3 publications

(2 citation statements)

References 195 publications

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“…The results showed that Bifidobacterium breve could enhance the synergistic effect of these antibiotics through a combination of probiotic and antibiotic metabolites, promoting a greater antibacterial effect against Gram-negative or Gram-positive pathogens. However, the idea remains that probiotics are safer and more effective when they intervene after using antibiotics to combat infection, acting as an adjuvant [131].…”

Section: Probioticsmentioning

confidence: 99%

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Matias,

Damasceno,

Pereira

et al. 2024

Biomedicines

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Antibiotics comprise one of the most successful groups of pharmaceutical products. Still, they have been associated with developing bacterial resistance, which has become one of the most severe problems threatening human health today. This context has prompted the development of new antibiotics or co-treatments using innovative tools to reverse the resistance context, combat infections, and offer promising antibacterial therapy. For the development of new alternatives, strategies, and/or antibiotics for controlling bacterial growth, it is necessary to know the target bacteria, their classification, morphological characteristics, the antibiotics currently used for therapies, and their respective mechanisms of action. In this regard, genomics, through the sequencing of bacterial genomes, has generated information on diverse genetic resources, aiding in the discovery of new molecules or antibiotic compounds. Nanotechnology has been applied to propose new antimicrobials, revitalize existing drug options, and use strategic encapsulating agents with their biochemical characteristics, making them more effective against various bacteria. Advanced knowledge in bacterial sequencing contributes to the construction of databases, resulting in advances in bioinformatics and the development of new antimicrobials. Moreover, it enables in silico antimicrobial susceptibility testing without the need to cultivate the pathogen, reducing costs and time. This review presents new antibiotics and biomedical and technological innovations studied in recent years to develop or improve natural or synthetic antimicrobial agents to reduce bacterial growth, promote well-being, and benefit users.

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Section: Probioticsmentioning

confidence: 99%

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Matias,

Damasceno,

Pereira

et al. 2024

Biomedicines

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“…Numerous studies have focused on investigating the potential impact of L. plantarum in managing diverse gastrointestinal disorders, including infectious diarrhea, antibiotic-associated diarrhea, irritable bowel syndrome (IBS), and inflammatory bowel disease (Ji et al, 2023 ; Kumar et al, 2023 ; Yang et al, 2023 ). L. plantarum 299v ameliorated Escherichia coli -induced intestinal permeability in rats, mitigating a 53% surge in mannitol permeation through the intestinal barrier, as gauged using Ussing chambers (Mangell et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Unraveling the antimicrobial potential of Lactiplantibacillus plantarum strains TE0907 and TE1809 sourced from Bufo gargarizans: advancing the frontier of probiotic-based therapeutics

Huang,

Zhao,

Hou

et al. 2024

Front. Microbiol.

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IntroductionIn an era increasingly defined by the challenge of antibiotic resistance, this study offers groundbreaking insights into the antibacterial properties of two distinct Lactiplantibacillus plantarum strains, TE0907 and TE1809, hailing from the unique ecosystem of Bufo gargarizans. It uniquely focuses on elucidating the intricate components and mechanisms that empower these strains with their notable antibacterial capabilities.MethodsThe research employs a multi-omics approach, including agar diffusion tests to assess antibacterial efficacy and adhesion assays with HT-29 cells to understand the preliminary mechanisms. Additionally, gas chromatography-mass spectrometry (GC-MS) is employed to analyze the production of organic acids, notably acetic acid, and whole-genome sequencing is utilized to identify genes linked to the biosynthesis of antibiotics and bacteriocin-coding domains.ResultsThe comparative analysis highlighted the exceptional antibacterial efficacy of strains TE0907 and TE1809, with mean inhibitory zones measured at 14.97 and 15.98 mm, respectively. A pivotal discovery was the significant synthesis of acetic acid in both strains, demonstrated by a robust correlation coefficient (cor ≥ 0.943), linking its abundance to their antimicrobial efficiency. Genomic exploration uncovered a diverse range of elements involved in the biosynthesis of antibiotics similar to tetracycline and vancomycin and potential regions encoding bacteriocins, including Enterolysin and Plantaricin.ConclusionThis research illuminates the remarkable antibacterial efficacy and mechanisms intrinsic to L. plantarum strains TE0907 and TE1809, sourced from B. gargarizans. The findings underscore the strains' extensive biochemical and enzymatic armamentarium, offering valuable insights into their role in antagonizing enteric pathogens. These results lay down a comprehensive analytical foundation for the potential clinical deployment of these strains in safeguarding animal gut health, thereby enriching our understanding of the role of probiotic bacteria in the realm of antimicrobial interventions.

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Efficacy of grapefruit seed extract and lactic acid bacteria in reducing Clostridioides difficile infection via gut microbiota modulation

Kang,

Zhao,

Liu

et al. 2024

Food Bioscience

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Strategies for applying probiotics in the antibiotic management of Clostridioides difficile infection

Abstract: The choice of the time interval between ‘bacteria and drug’ should be based on the metabolism of antibiotics, different probiotics, probiotic antimicrobial resistance and dosage, the baseline gut ecological environment, and the host immune level.

Cited by 3 publications

References 195 publications

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Unraveling the antimicrobial potential of Lactiplantibacillus plantarum strains TE0907 and TE1809 sourced from Bufo gargarizans: advancing the frontier of probiotic-based therapeutics

Efficacy of grapefruit seed extract and lactic acid bacteria in reducing Clostridioides difficile infection via gut microbiota modulation

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