Strategies and techniques to mitigate the negative impacts of pesticide exposure to honey bees

Zhang, Ge; Olsson, Rae L; Hopkins, Brandon K.

doi:10.1016/j.envpol.2022.120915

Cited by 13 publications

(11 citation statements)

References 164 publications

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“…44 Unfortunately, the welldocumented abatement in pollinators has emerged globally. 45,46 The factors, including hazardous substances, pathogens, and parasites, especially chemical pesticides, are vital reasons for the decline in bee populations. 45 Furthermore, the most common pesticide residues in bees were organophosphate insecticides such as malathion, parathion, dimethoate.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Thus, the A. mellifera , as one of the most important pollinators, play a crucial role in agricultural productivity and ecosystem stability . Unfortunately, the well-documented abatement in pollinators has emerged globally. , The factors, including hazardous substances, pathogens, and parasites, especially chemical pesticides, are vital reasons for the decline in bee populations . Furthermore, the most common pesticide residues in bees were organophosphate insecticides such as malathion, parathion, dimethoate. , Therefore, in this study, A. mellifera was used for environmental toxicology research.…”

Section: Resultsmentioning

confidence: 99%

“…Unfortunately, the well-documented abatement in pollinators has emerged globally. , The factors, including hazardous substances, pathogens, and parasites, especially chemical pesticides, are vital reasons for the decline in bee populations . Furthermore, the most common pesticide residues in bees were organophosphate insecticides such as malathion, parathion, dimethoate. , Therefore, in this study, A. mellifera was used for environmental toxicology research. Fortunately, 6-methylcoumarin, in this study, displayed no toxicity, whereas malathion possesses potent toxicity to honeybees, demonstrating that 6-methylcoumarin can be developed as a green potential aphicide substitute, thus reducing the negative effects of highly toxic pesticides on bees.…”

Section: Resultsmentioning

confidence: 99%

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Development of Sustainable Insecticide Candidates for Protecting Pollinators: Insight into the Bioactivities, Selective Mechanism of Action and QSAR of Natural Coumarin Derivatives against Aphids

Zhou,

Jian,

Shao

et al. 2023

J. Agric. Food Chem.

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Plants employ abundant toxic secondary metabolites to withstand insect attack, while pollinators can tolerate some natural defensive compounds. Coumarins, as promising green alternatives to chemical insecticides, possess wide application prospects in the crop protection field. Herein, the bioactivities of 30 natural coumarin derivatives against Aphis gossypii were assessed and revealed that 6-methylcoumarin exhibited potent aphicidal activity against aphids but displayed no toxicity to honeybees. Additionally, using biochemical, bioinformatic, and molecular assays, we confirmed that the action mode of 6-methylcoumarin against aphids was by inhibiting acetylcholinesterase (AChE). Meanwhile, functional assays revealed that the difference in action site, which located in Lys585 in aphid AChE (equivalent to Val548 in honeybee AChE), was the principal reason for 6-methylcoumarin being toxic to aphids but safe to pollinators. This action site was further validated by mutagenesis data, which uncovered how 6-methylcoumarin was unique selective to the aphid over honeybee or mammalian AChE. Furthermore, a 2D-QSAR model was established, revealing that the central structural feature was H3m, which offers guidance for the future design of more potent coumarin compounds. This work provides a sustainable strategy to take advantage of coumarin analogues for pest management while protecting nontarget pollinators.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Development of Sustainable Insecticide Candidates for Protecting Pollinators: Insight into the Bioactivities, Selective Mechanism of Action and QSAR of Natural Coumarin Derivatives against Aphids

Zhou,

Jian,

Shao

et al. 2023

J. Agric. Food Chem.

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“…To address this issue, proper management of the comb is critical. Old comb can be culled or pesticide residues in old comb can be remediated using methods such as ozone and radiation in order to protect bees in early developmental stages …”

Section: Impact Of Gut Hive and Landscape Environment And Bee Sociali...mentioning

confidence: 99%

“…1,2 Emerging pharmaceutical treatments using phytochemicals, probiotics (beneficial bacteria) and recombinant proteins (enzymes) to detoxify pesticides hold promise to mitigate pesticide poisonings in bees. 3 All three treatments examined in this Perspective (hereinafter abbreviated as 3P) use similar detoxification mechanisms that rely on enzymes to break down, transform, or mineralize pesticides (Figure 1). These enzymes include (1) endogenous bee enzymes which are expressed by their detoxification genes and can be enhanced by phytochemicals 4−6 and (2) intracellular enzymes that are produced by bacteria residing in the guts of honey bees or free recombinant proteins with enzymatic capability that can be fed to bees (Figure 1).…”

Section: ■ Introductionmentioning

confidence: 99%

Phytochemicals, Probiotics, Recombinant Proteins: Enzymatic Remedies to Pesticide Poisonings in Bees

Zhang,

Dilday,

Kuesel

et al. 2023

Environ. Sci. Technol.

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The ongoing global decline of bees threatens biodiversity and food safety as both wild plants and crops rely on bee pollination to produce viable progeny or high-quality products in high yields. Pesticide exposure is a major driving force for the decline, yet pesticide use remains unreconciled with bee conservation since studies demonstrate that bees continue to be heavily exposed to and threatened by pesticides in crops and natural habitats. Pharmaceutical methods, including the administration of phytochemicals, probiotics (beneficial bacteria), and recombinant proteins (enzymes) with detoxification functions, show promise as potential solutions to mitigate pesticide poisonings. We discuss how these new methods can be appropriately developed and applied in agriculture from bee biology and ecotoxicology perspectives. As countless phytochemicals, probiotics, and recombinant proteins exist, this Perspective will provide suggestive guidance to accelerate the development of new techniques by directing research and resources toward promising candidates. Furthermore, we discuss practical limitations of the new methods mentioned above in realistic field applications and propose recommendations to overcome these limitations. This Perspective builds a framework to allow researchers to use new detoxification techniques more efficiently in order to mitigate the harmful impacts of pesticides on bees.

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You are what you eat – The influence of polyphagic and monophagic diet on the flight performance of bees

Krüger,

Buchholz,

Schmitt

et al. 2024

Ecology and Evolution

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Movement performance of insects is an important measure of physiological fitness and is likely affected by novel stressors associated with global change. Reduced fitness can lead to smaller foraging areas and thus to decreasing abundance, diversity and nutritional quality, which could weaken insect populations and contribute to global insect decline. Here, we combined two different methods: An experimental semi‐field design applying treatments in outdoor flight cages and a follow‐up experiment conducted in the laboratory, in which different parameters of movement performance, such as (a) velocity, (b) duration and (c) distance of an insect's flight can be quantified. We kept colonies of the bumblebee Bombus terrestris under contrasting nutritional conditions and measured treatment effects on the movement performance of individuals. Monophagously fed bumblebees showed reduced movement performance than polyphagously fed bumblebees. In particular, they stopped more frequently during flight, flew shorter distances and showed less often flight duration of 20 min. Our results suggest that nutritional deficiency due to a monophagic diet leads to reduced flight performance, which can have dramatic negative consequences for bees. Reduced flight performance may result in decreased availability of host plants, which may negatively affect stress resistance of bees and brood provisioning, facilitating extinction of insects. Although food of great nutritional value is an important compensator for the negative effects of different novel stressor, such as pesticides, it is not much known how to compensate for the effects of nutritional stress, especially in landscapes dominated by monocultures. However, our experimental approach with semi‐field and laboratory components has high potential for further studies investigating the impact of different stressors on the physiological fitness of insects but also body mass, or reproductive success and to find factors that may mitigate or even overcome the negative effect of stressors on insects.

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Strategies and techniques to mitigate the negative impacts of pesticide exposure to honey bees

Cited by 13 publications

References 164 publications

Development of Sustainable Insecticide Candidates for Protecting Pollinators: Insight into the Bioactivities, Selective Mechanism of Action and QSAR of Natural Coumarin Derivatives against Aphids

Development of Sustainable Insecticide Candidates for Protecting Pollinators: Insight into the Bioactivities, Selective Mechanism of Action and QSAR of Natural Coumarin Derivatives against Aphids

Phytochemicals, Probiotics, Recombinant Proteins: Enzymatic Remedies to Pesticide Poisonings in Bees

You are what you eat – The influence of polyphagic and monophagic diet on the flight performance of bees

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