Strategies and perspectives of developing anti-biofilm materials for improved food safety

Ma, Yue; Aslam, Muhammad Zohaib; Wu, Mengjie; Nitin, Nitin; Sun, Gang

doi:10.1016/j.foodres.2022.111543

Cited by 13 publications

(9 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among various antimicrobial agents, N -halamines have gained attention for their capacity to generate active antimicrobial species upon interaction with microorganisms. Current N -halamine materials are effective in antimicrobial applications but are mostly made of synthetic substrates. − A promising alternative approach is the use of biobased materials like proteins to form N -halamine structures, which can offer the desired functions and environmental benefits to food-contact surfaces . Proteins such as gelatin and soy protein hydrolysate (SPH), rich in primary and secondary amines, are attractive substrates for functionalization with N -halamines. − Tannic acid (TA) serves as a food-grade crosslinking agent, stabilizing these proteins through Michael addition or Schiff base reactions .…”

Section: Introductionmentioning

confidence: 99%

Protein-Based Rechargeable and Replaceable Antimicrobial and Antifouling Coatings on Hydrophobic Food-Contact Surfaces

Zou,

Wong,

Lee

et al. 2024

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

The growing concerns regarding foodborne illnesses related to fresh produce accentuate the necessity for innovative material solutions, particularly on surfaces that come into close contact with foods. This study introduces a sustainable, efficient, and removable antimicrobial and antifouling coating ideally suited for hydrophobic food-contact surfaces such as low-density polyethylene (LDPE). Developed through a crosslinking reaction involving tannic acid, gelatin, and soy protein hydrolysate, these coatings exhibit proper stability in aqueous washing solutions and effectively combat bacterial contamination and prevent biofilm formation. The unique surface architecture promotes the formation of halamine structures, enhancing antimicrobial efficacy with a rapid contact killing effect and reducing microbial contamination by up to 5 log 10 cfu•cm −2 against both Escherichia coli (Gram-negative) and Listeria innocua (Gram-positive). Notably, the coatings are designed for at least five recharging cycles under mild conditions (pH6, 20 ppm free active chlorine) and can be easily removed with hot water or steam to refresh the depositions. This removal process not only conveniently aligns with existing sanitation protocols in the fresh produce industry but also facilitates the complete eradication of potential developed biofilms, outperforming uncoated LDPE coupons. Overall, these coatings represent sustainable, cost-effective, and practical advancements in food safety and are promising candidates for widespread adoption in food processing environments.

show abstract

Section: Introductionmentioning

confidence: 99%

Protein-Based Rechargeable and Replaceable Antimicrobial and Antifouling Coatings on Hydrophobic Food-Contact Surfaces

Zou,

Wong,

Lee

et al. 2024

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Researchers have developed different types of antimicrobial agents for treating infections of traumatic surfaces against bacteria and biofilms. Commonly used antimicrobial agents are classified into three categories based on the type of materials used: inorganic, biological, and organic antimicrobial agents [ 12 ]. Inorganic antimicrobial agents can be divided into two categories: metal-based and carbon-based.…”

Section: Introductionmentioning

confidence: 99%

“…Typical materials include silver nanoparticles, titanium dioxide nanoparticles, graphene, etc. However, the use of these inorganic antimicrobial agent materials is accompanied by high manufacturing costs, short and insufficient antimicrobial capacity, and an unknown impact on human health and the environment [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Biological antibacterial agents, such as enzymes, peptides, and bacteriophages, originate from living organisms.…”

Section: Introductionmentioning

confidence: 99%

“…So, biological antibacterial agents have a wider range of applications. However, the use of biological antibacterial agents is expensive and limited by the longevity of their biological sources and environmental factors [ 12 , 19 , 20 , 21 ]. Organic antibacterial agents can be divided into synthetic and naturally derived materials.…”

Section: Introductionmentioning

confidence: 99%

“…Organic antibacterial agents can be divided into synthetic and naturally derived materials. Synthetic organic antibacterial agents include common organic antimicrobials, such as penicillin and amoxicillin, which are widely used but prone to developing resistance in pathogenic bacteria [ 11 , 12 , 22 ]. Among naturally derived organic antimicrobial agents, essential oils have gained widespread interest due to their low toxicity, broad-spectrum antibacterial activity, multiple pharmacological activities, and relatively low cost [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Essential Oil Nanoemulsion Hydrogel with Anti-Biofilm Activity for the Treatment of Infected Wounds

et al. 2023

View full text Add to dashboard Cite

The formation of a bacterial biofilm on an infected wound can impede drug penetration and greatly thwart the healing process. Thus, it is essential to develop a wound dressing that can inhibit the growth of and remove biofilms, facilitating the healing of infected wounds. In this study, optimized eucalyptus essential oil nanoemulsions (EEO NEs) were prepared from eucalyptus essential oil, Tween 80, anhydrous ethanol, and water. Afterward, they were combined with a hydrogel matrix physically cross-linked with Carbomer 940 (CBM) and carboxymethyl chitosan (CMC) to prepare eucalyptus essential oil nanoemulsion hydrogels (CBM/CMC/EEO NE). The physical-chemical properties, in vitro bacterial inhibition, and biocompatibility of EEO NE and CBM/CMC/EEO NE were extensively investigated and the infected wound models were proposed to validate the in vivo therapeutic efficacy of CBM/CMC/EEO NE. The results showed that the average particle size of EEO NE was 15.34 ± 3.77 nm with PDI ˂ 0.2, the minimum inhibitory concentration (MIC) of EEO NE was 15 mg/mL, and the minimum bactericidal concentration (MBC) against S. aureus was 25 mg/mL. The inhibition and clearance of EEO NE against S. aureus biofilm at 2×MIC concentrations were 77.530 ± 7.292% and 60.700 ± 3.341%, respectively, demonstrating high anti-biofilm activity in vitro. CBM/CMC/EEO NE exhibited good rheology, water retention, porosity, water vapor permeability, and biocompatibility, meeting the requirements for trauma dressings. In vivo experiments revealed that CBM/CMC/EEO NE effectively promoted wound healing, reduced the bacterial load of wounds, and accelerated the recovery of epidermal and dermal tissue cells. Moreover, CBM/CMC/EEO NE significantly down-regulated the expression of two inflammatory factors, IL-6 and TNF-α, and up-regulated three growth-promoting factors, TGF-β1, VEGF, and EGF. Thus, the CBM/CMC/EEO NE hydrogel effectively treated wounds infected with S. aureus, enhancing the healing process. It is expected to be a new clinical alternative for healing infected wounds in the future.

show abstract

Application of biofilm dispersion-based nanoparticles in cutting off reinfection

Li,

Lin,

Wang

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Bacterial biofilms commonly cause chronic and persistent infections in humans. Bacterial biofilms consist of an inner layer of bacteria and an autocrine extracellular polymeric substance (EPS). Biofilm dispersants (abbreviated as dispersants) have proven effective in removing the bacterial physical protection barrier EPS. Dispersants are generally weak or have no bactericidal effect. Bacteria dispersed from within biofilms (abbreviated as dispersed bacteria) may be more invasive, adhesive, and motile than planktonic bacteria, characteristics that increase the probability that dispersed bacteria will recolonize and cause reinfection. The dispersants should be combined with antimicrobials to avoid the risk of severe reinfection. Dispersant-based nanoparticles have the advantage of specific release and intense penetration, providing the prerequisite for further antibacterial agent efficacy and achieving the eradication of biofilms. Dispersant-based nanoparticles delivered antimicrobial agents for the treatment of diseases associated with bacterial biofilm infections are expected to be an effective measure to prevent reinfection caused by dispersed bacteria. Key points • Dispersed bacteria harm and the dispersant’s dispersion mechanisms are discussed. • The advantages of dispersant-based nanoparticles in bacteria biofilms are discussed. • Dispersant-based nanoparticles for cutting off reinfection in vivo are highlighted.

show abstract

Strategies and perspectives of developing anti-biofilm materials for improved food safety

Cited by 13 publications

References 114 publications

Protein-Based Rechargeable and Replaceable Antimicrobial and Antifouling Coatings on Hydrophobic Food-Contact Surfaces

Protein-Based Rechargeable and Replaceable Antimicrobial and Antifouling Coatings on Hydrophobic Food-Contact Surfaces

Essential Oil Nanoemulsion Hydrogel with Anti-Biofilm Activity for the Treatment of Infected Wounds

Application of biofilm dispersion-based nanoparticles in cutting off reinfection

Contact Info

Product

Resources

About