Strategies and Challenges in Measuring Protein Abundance Using Stable Isotope Labeling and Tandem Mass Spectrometry

Kristjansdottir, Kolbrun; Takahashi, Satoe; Volchenboum, Samuel L.; Kron, Stephen J.

doi:10.5772/33421

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Data Analysis and Interpretation1

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2024

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“…Linear dynamic range or the portion of the curve where the biosensor response changes linearly with analyte concentration. , The boundaries of linear range include upper and lower limit of quantitation as shown in Figure b.…”

Section: Data Analysis and Interpretationmentioning

confidence: 99%

Strategy, Design, and Fabrication of Electrochemical Biosensors: A Tutorial

Sankar,

Kuzmanović,

Schaus

et al. 2024

ACS Sens.

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Advanced healthcare requires novel technologies capable of real-time sensing to monitor acute and long-term health. The challenge relies on converting a real-time quantitative biological and chemical signal into a desired measurable output. Given the success in detecting glucose and the commercialization of glucometers, electrochemical biosensors continue to be a mainstay of academic and industrial research activities. Despite the wealth of literature on electrochemical biosensors, reports are often specific to a particular application (e.g., pathogens, cancer markers, glucose, etc.), and most fail to convey the underlying strategy and design, and if it is transferable to detection of a different analyte.Here we present a tutorial review for those entering this research area that summarizes the basic electrochemical techniques utilized as well as discusses the designs and optimization strategies employed to improve sensitivity and maximize signal output.

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Section: Data Analysis and Interpretationmentioning

confidence: 99%