Stratégie diagnostique des sarcomes des tissus mous de l’enfant et adolescent

Collignon, Charlotte; Brisse, H.; Lemelle, Lauriane; Cardoen, Liesbeth; Gauthier, Arnaud; Roussel, Anne Marie; Dumont, Benoît; Alimi, Aurélia; Cordero, Camille; Rouffiange, Lucie; Orbach, Daniel

doi:10.1016/j.bulcan.2020.06.008

Cited by 4 publications

(1 citation statement)

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“…The initial diagnostic workup is crucial in diagnosing malignant soft-tissue tumors such as sarcomas 7 . Clinical examination can be limited to characterizing deep soft-tissue masses, for example, complementary imaging investigations are important in providing evidence for a potential malignant origin and guiding the need for a biopsy 8 .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound performance in pediatric deep soft-tissue tumor characterization

Li,

Chen,

Jin

et al. 2023

Sci Rep

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This study investigated the performance of ultrasonography in diagnosing deep soft-tissue tumors and tumor-like lesions in children with histological results. Demographic information and ultrasound characteristics of benign and malignant masses were statistically analyzed. Three radiologists (Radiologists 1, 2, and 3) independently reviewed the ultrasonography studies while being blinded to the medical history and other imaging findings. The 82 lesions included in the study were histopathologically classified as malignant (n = 25) or benign (n = 57). No statistically significant differences were observed between the benign and malignant subgroups regarding age (p = 0.059), sex (p = 1.0), disease course (p = 0.812), presence or absence of symptoms (p = 0.534), maximum diameter (p = 0.359), margin (p = 1.0), calcification (p = 0.057), or blood Adler type (p = 0.563). However, statistically significant differences were observed between the benign and malignant subgroups in terms of isolated or Multiple occurrences (p < 0.001), history of malignancy (p < 0.001), shape (p < 0.001), and echogenicity (p < 0.001). Parameters such as tumor shape (p = 0.042, OR = 6.222), single or multiple occurrences (p = 0.008, OR = 17.000), and history of malignancy (p = 0.038, OR = 13.962) were identified as independent predictors of benign and malignant tumors. The diagnostic sensitivities evaluated by the three radiologists were 68.0%, 72.0%, 96.0%, respectively, while the specificities were 77.2%, 82.5%, 77.2%, respectively. Ultrasound demonstrates good performance in the diagnosis of benign deep lesions such as hemangiomas/venous malformation and adipocytic tumors. Multiple irregular morphologies and a history of malignancy were identified as independent risk factors for malignant masses. The experience of radiologists in recognizing specific tumors is important. Careful attention should be paid to masses with ambiguous ultrasound features, as well as small lesions.

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Section: Introductionmentioning

confidence: 99%