PurposeThis study mainly aims to explore the causal nexus between big data-driven organizational capabilities (BDDOC) and supply chain innovation capabilities (SCIC) and innovation performance (IP), then explore the indirect effect of SCIC and also test the moderating effects for both internal supply chain integration (ISCI) and external supply chain integration (ESCI) into the relationship between BDDOC and SCIC.Design/methodology/approachIn order to test the conceptual model and the hypothesized relationships between all the constructs, the data were collected using a self-reported questionnaire by workers in Jordanian small and medium manufacturing enterprises. Partial least squares-structural equation modeling (PLS-SEM) was employed to test the model.FindingsThe paper reached a set of interesting results where it was confirmed that there is a positive and statistically significant relationship between BDDOC, SCIC and IP in addition to confirming the indirect effect of SCIC between BDDOC and IP. The results also showed that there is a moderating role for both ESCI and ISCI.Originality/valueThis study can be considered the first study in the current literature that investigates these constructs as shown in the research model. Therefore, the paper presents an interesting set of theoretical and managerial contributions that may contribute to covering part of the research gap in the literature.