Strain-rate and temperature dependent material properties of Agar and Gellan Gum used in biomedical applications

Schiavi, Alessandro; Cuccaro, R.; Troia, Adriano

doi:10.1016/j.jmbbm.2015.08.011

Cited by 35 publications

(24 citation statements)

References 31 publications

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“…A comprehensive understanding of such behaviour is crucial since they are expected to be exposed to complex loading conditions of body environment [16]. Several experimental studies were performed to characterise viscoelastic properties of biological hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Through-thickness stress relaxation in bacterial cellulose hydrogel

Gao

Kuśmierczyk

Shi

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Biological hydrogels, e.g. bacterial cellulose (BC) hydrogel, attracted increasing interest in recent decades since they show a good potential for biomedical engineering as replacements of real tissues thanks mainly to their good biocompatibility and fibrous structure. To select potential candidates for such applications, a comprehensive understanding of their performance under application-relevant conditions is needed. Most hydrogels demonstrate time-dependent behaviour due to the contribution of their liquid phase and reorientation of fibres in a process of their deformation. To quantify such time-dependent behaviour is crucial due to their exposure to complicated loading conditions in body environment. Some hydrogel-based biomaterials with a multi-layered fibrous structure demonstrate a promise as artificial skin and blood vessels. The results show a good potential to use a fraction-exponential model to describe such behaviour of multi-layered hydrogels, especially at stages of stress decay at low forces and of stress equilibrium at high forces.

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Section: Introductionmentioning

confidence: 99%

Through-thickness stress relaxation in bacterial cellulose hydrogel

Gao

Kuśmierczyk

Shi

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…For all the experiments, Phytagel-based growth media were elaborated. We used Phytagel as a substitute for Agar for its higher temperature stability, higher mechanical strength and better optical clarity (Schiavi et al ., 2016). The growth medium consisted of half-strength Murashige and Skoog (MS/2) medium adjusted to pH 5.7 and containing Phytagel at different concentrations.…”

Section: Methodsmentioning

confidence: 99%

“…In the linear portion of the curve, i.e . when stress is proportional to strain, deformation is considered to be elastic (Schiavi et al ., 2016). In this range, the elastic modulus (E) value of the Phytagel samples was determined from the ratio between the incremental stress Δs and the incremental strain rate Δε according to Hooke’s law: …”

Section: Methodsmentioning

confidence: 99%

“…The elaboration of a two-layer Phytagel-based growth medium, containing two layers of distinct Phytagel concentrations, enables the roots to experience variations in medium strength when penetrating from one medium layer to another (Yamamoto et al ., 2008; Yan et al ., 2017). It has been shown that adjusting the Phytagel concentration modulated growth medium strength (Schiavi et al ., 2016). In two-layer media experiments, where roots faced a compliant layer and a stiff layer consecutively, root tips were submitted to increasing axial stress as they encountered the interface between the two layers.…”

Section: Introductionmentioning

confidence: 99%

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The cap size and shape of Arabidopsis thaliana primary roots impact the root responses to an increase in medium strength

Roue

Chauvet

Brunel-Michac

et al. 2018

Preprint

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During root progression in soil, root cap cells are the first to encounter obstacles. The root cap is known to sense environmental cues, making it a relevant candidate for a mechanosensing site. An original two-layer medium was developed in order to study root responses to growth medium strength and the importance of the root cap in the establishment of these responses. Root growth and trajectory of primary roots of Arabidopsis thaliana seedlings were investigated using in vivo image analysis. After contact with the harder layer, the root either penetrated it or underwent rapid curvature, enabling reorientation of the root primary growth. The role of the root cap in tip reorientation was investigated by analyzing the responses of Arabidopsis mutant roots with altered caps. The primary root of fez-2 mutant lines, which has fewer root cap cell layers than wild-type roots, showed impaired penetration ability. Conversely, smb-3 roots of mutant lines, which display a higher number of root cap cells, showed enhanced penetration abilities. This work highlights that alterations in root cap shape and size affect the root responses to medium strength.HighlightThe analysis of the growth and orientation of Arabidopsis thaliana mutant roots affected in root cap size and shape showed that properly formed root cap is required to trigger the root responses to medium strength.AbbreviationsCOLcolumella;LRCLateral Root Cap;SISharpness Index;SMBSOMBRERO.

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“…Since the BC hydrogel consists of solid and liquid phases, it demonstrates time-dependent behaviour thanks to the contribution of water. Considering its potential applications, it is essential to determine viscoelastic properties as well as time-dependent behaviour [17]. In a study of Nimeskern et al [8], stress-relaxation indentation was performed to characterize viscoelastic properties of the BC with various cellulose contents for evaluation of potential use for ear-cartilage replacement.…”

Section: Introductionmentioning

confidence: 99%

Effect of microstructure on anomalous strain-rate-dependent behaviour of bacterial cellulose hydrogel

Gao

Shi

Lau

et al. 2016

Materials Science and Engineering: C

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This study is focused on anomalous strain-rate-dependent behaviour of bacterial cellulose (BC) hydrogel that can be strain-rate insensitive, hardening, softening, or strain-rate insensitive in various ranges of strain rate. BC hydrogel consists of randomly distributed nanofibres and a large content of free water; thanks to its ideal biocompatibility, it is suitable for biomedical applications. Motivated by its potential applications in complex loading conditions of body environment, its time-dependent behaviour was studied by means of inaqua uniaxial tension tests at constant temperature of 37°C at various strain rates ranging from 0.0001 s -1 to 0.3 s -1 . Experimental results reflect anomalous strain-rate-dependent behaviour that was not documented before. Micro-morphological observations allowed identification of deformation mechanisms at low and high strain rates in relation to microstructural changes. Unlike strain-rate softening behaviours in other materials, reorientation of nanofibres and kinematics of free-water flow dominate the softening behaviour of BC hydrogel at high strain rates.

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Strain-rate and temperature dependent material properties of Agar and Gellan Gum used in biomedical applications

Cited by 35 publications

References 31 publications

Through-thickness stress relaxation in bacterial cellulose hydrogel

Through-thickness stress relaxation in bacterial cellulose hydrogel

The cap size and shape of Arabidopsis thaliana primary roots impact the root responses to an increase in medium strength

Effect of microstructure on anomalous strain-rate-dependent behaviour of bacterial cellulose hydrogel

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