Strain differences of dopamine receptor levels and dopamine related behaviors in rats

Zamudio, Sergio; Fregoso, Tomás; Miranda, Abraham; Cruz, Fidel de la; Flores, Gonzalo

doi:10.1016/j.brainresbull.2005.01.009

Cited by 36 publications

(27 citation statements)

References 56 publications

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“…4, the difference in the binding potential between these strains could be owing to the difference in specifi c binding (striatal minus cerebellar radioactivity) between the strains. This fi nding is in part supported by autographic studies demonstrating that Wistar rats exhibited higher D 2 receptor levels than SD rats in the dorsolateral part of the caudate-putamen [34]. On the other hand, higher binding potential in adult Wistar rats than in senescent F344 rats was observed.…”

Section: Discussionsupporting

confidence: 48%

An atlas-based image registration method for dopamine receptor imaging with PET in rats

et al. 2007

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For analysis of in vivo dopamine receptor binding in the rat brain by positron emission tomography (PET), a convenient method to obtain precise anatomical registration for striatum and cerebellum on the PET image was developed. On the PET measurements, a control, an anesthetized rat was positioned in a stereotaxic holder so that the horizontal plane of the PET image would be parallel to the horizontal plane of the brain atlas. After the positioning, [11C]raclopride was intravenously injected into the rats and scanned to obtain PET images of dopamine D2 receptor in the brain. The striatum was bilaterally identified in the obtained PET image. The atlas-based regions of interest (ROIs) of the whole brain were preliminarily created according to the atlas, and were superimposed on an early phase PET image. The early phase PET image was compatible to the whole brain ROI in the atlas, which enabled determination of striatal and cerebellar ROI difficult to determine by the PET image alone. Using the cerebellar radioactivity as a reference input function, rate constants between the free/nonspecific compartment and the receptor bound compartment (k3 and k4) were calculated by a two-parameter compartment model, and the binding potential (k3/k4) was estimated. The binding potential and its coefficients of variation were 1.56+/-0.30, 19.3% in Wistar rats, 1.05+/-0.14, 13.4% in Sprague-Dawley (SD) rats, and 1.29+/-0.07, 5.2% in Fischer F344 rats, in which binding potential in Wistar rats was significantly higher than that in SD rats. This method is objective and convenient in routine use for PET studies in rats, regardless of differences in the rat strains.

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Section: Discussionsupporting

confidence: 48%

An atlas-based image registration method for dopamine receptor imaging with PET in rats

et al. 2007

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“…It is suggested that buprenorphine interacts with the central dopaminergic systems, thereby depressing the central nervous system (Cowan et al 1977b, Bartoletti et al 1999. Rat strain differences in dopamine (DA) receptor levels and resulting differences in behaviour have been described (Zamudio et al 2005). In addition, Baumann et al (2000) found that opiate modulation of the hypothalamic-pituitary-adrenal axis (HPA) and mesolimbic DA function can be straindependent as well.…”

Section: Discussionmentioning

confidence: 99%

The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains

et al. 2008

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SummaryBuprenorphine is a partial m, k agonist that has been shown to influence spontaneous behaviour in animals. Previously, we have demonstrated significant differences in the analgesic response to buprenorphine between the August Copenhagen Irish (ACI)/SegHsd and the Brown Norway (BN)/RijHsd inbred rat strains. The purpose of this study was to determine whether these strains also differed in their behavioural response to buprenorphine in order to provide an additional parameter for the genetic analysis and localization of genes involved in this response. Male and female rats of both strains were used (n ¼ 6/strain/sex) for this study. Each rat was subjected, respectively, to three treatment regimens at 15:00 h: (A) unchallenged; (B) intravenous saline; (C) intravenous buprenorphine (0.05 mg/kg) according to a crossover design. The relative duration (s/h) of locomotion, grooming, drinking and eating behaviour was subsequently determined from 15:30 to 07:00 h using the automatic registration system, Laboratory Animal Behaviour Registration and Analysis System TM . Significant strain differences were observed in unchallenged behaviour between the ACI and the BN rats. ACI rats, but not BN rats, responded to buprenorphine treatment with decreased levels of locomotion, drinking and eating behaviour. The same treatment resulted in an increased grooming behaviour in both strains. Slight but significant sex differences were observed for locomotion and eating in the analysis of variance procedure, but did not reach the level of statistical significance in the multiple comparison procedure. The results of this study emphasize the possibility that strain-specific effects must be taken into account when using behavioural parameters for the assessment of the analgesic effects of buprenorphine in rats.

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“…30 In addition, immobility responses are keen behavioral tests that show a general idea of the status of the dopaminergic system since the prepuberal age, because immobility responses are modulated by structures such as the basal nuclei and nucleus accumbens. 22,31 The open-fi eld test in an unknown environment is another test to evaluate emotion in rats. We found that the nVH lesion with lidocaine causes an increase of the distance traveled because reset time decreased and both ambulatory and nonambulatory times are enhanced.…”

Section: Discussionmentioning

confidence: 99%

“…When animal stopped moving, the time of immobility was recorded until the animal made escape-like movements directed at the experimenter's hand or until 180s had elapsed. 22 Open-fi eld test in an unknown environment (P35 and P58)…”

Section: Dorsal Immobility (P34 and P57)mentioning

confidence: 99%

Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders

Ortiz-Butrón¹

2008

NDT

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Abstract:Our aim was to investigate if neonatal bilateral administration of lidocaine into the ventral hippocampus would cause behavioral changes related to schizophrenia. A neonatal ventral-hippocampal lesion (nVH lesion) was made with lidocaine in Wistar male pups. Two groups were formed, the fi rst received lidocaine (4 μg/0.3 μL) and the second an equal volume of vehicle. At day 35 and 56, both groups were tested for social contact, immobility caused by clamping the neck and dorsal immobility, locomotor activity in an open fi eld, and tail fl ick (TF) latency after a painful heat stimulus. All animals were then killed. Coronal cuts (7 μm) of the brain were obtained and each brain section was stained with cresyl violet-eosin. The animals which received the nVH lesion with lidocaine had decreased social interaction at both ages. The rats with lesions, only at day 58 postnatal, increased their distance traveled and ambulatory time, with a decrease in their nonambulatory and reset time. The rats with lesions had a longer duration of immobility caused by clamping the neck and a longer dorsal immobility at both days 34 and 57 compared to control rats. The lidocaine-treated group spent less time to defl ect the tail compared to the control group at postpubertal age. The neonatal bilateral administration of lidocaine into the ventral hippocampus caused some alterations, such as chromatin condensation, nucleolus loss, and cell shrinkage, but glial proliferation was not seen. Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes.

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Strain differences of dopamine receptor levels and dopamine related behaviors in rats

Cited by 36 publications

References 56 publications

An atlas-based image registration method for dopamine receptor imaging with PET in rats

An atlas-based image registration method for dopamine receptor imaging with PET in rats

The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains

Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders

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