Strain differences in the mating behavior of Sprague-Dawley, Long-Evans, and Wistar male rats

McLean, Jack H.; Dupeire, Walter A.; Elder, S. Thomas

doi:10.3758/bf03342585

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…The most notable was the close-to-complete absence of the “mounting” pattern in male Wistar stocks. There is a report that male Wistar rats make fewer mountings and more intromissions than Sprague Dawley rats [ 4 ]. In addition, male Wistar rats needed more time and intromissions to achieve ejaculation.…”

Section: Discussionmentioning

confidence: 99%

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Choosing the Optimal Rat Stock as a Model for Research into Pharmacological Correction of Male Sexual Dysfunction

Zhuravleva¹,

Titova²,

Мухина³

et al. 2021

Sovrem Tehnol Med

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The aim of the study is to identify the mechanisms mediating differences in sexual behavior between Sprague Dawley and Wistar rats, in order to choose the optimal stock for research into pharmacological correction of male sexual dysfunction.Materials and Methods. The experiments were carried out on sexually mature male rats of two stocks (Sprague Dawley and Wistar) weighing 350-450 g and aged 3 to 6 months. The comparative study of animal behavior was performed using standard tests for social interaction, locomotor activity, and anxiety level, as well as male mating behavior patterns. In order to determine the role of hypothalamic glycine receptors in the male sexual behavior, pharmacological manipulations of glycine receptor activity during mating with receptive females were conducted via bilateral intracerebral microcannulas implanted in the medial preoptic area (mPOA) of the male rat anterior hypothalamus.Results. The obtained results revealed statistically significant inter-stock differences in sexual behavior at the final consummatory stage of both intact animals and those after pharmacological activation of glycine receptors in the mPOA. The number of anxiety-related grooming patterns in the Open Field test significantly differed between the stocks for both intact animals and those after pharmacological activation of glycine receptors; the observed differences disappeared after the mPOA glycine receptors were blocked. In the Crowley test of social interaction, no significant difference was found between the stocks.Thus, the revealed difference in sexual behavior between Sprague Dawley and Wistar male rats is likely due to the difference in the level of anxiety, which, in turn, may be associated with difference in the mechanisms of glycinergic neurotransmission in the hypothalamic mPOAs of these rats. Conclusion.To study the relationship between the level of anxiety and sexual behavior, the choice of the Wistar rat stock is optimal since the male sexual behavior in this stock is more sensitive to stress than that in Sprague Dawley rats. However, to model male sexual dysfunction not associated with anxiety, the use of Sprague Dawley male rats should be preferred as these animals show more stable sexual behavior, which is less dependent on the level of anxiety.

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Section: Discussionmentioning

confidence: 99%

“…Various aspects of sexual behavior are usually studied using the Sprague Dawley and Wistar rat outbred stocks. Despite its importance for selection of the optimal animal model, little is known about the difference in sexual behavior between rats of these two stocks [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Choosing the Optimal Rat Stock as a Model for Research into Pharmacological Correction of Male Sexual Dysfunction

Zhuravleva¹,

Titova²,

Мухина³

et al. 2021

Sovrem Tehnol Med

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show abstract

“…If genetic data are to be integrated with the mass of experimental and developmental data on copulatory behavior in rats, then the genetic determinants of copulatory behavior must be studied in rats. Two articles have reported strain differences in rat copulatory behavior (McLean, Dupeire, & Elder, 1972;Whalen, 1961), while one study was directed at selection for grid crossing to an opposite-sexed partner (Rasmussen, 1953).…”

Section: A Diallel Cross Analysis Of Genetic Determinants Of Copulato...mentioning

confidence: 99%

A diallel cross analysis of genetic determinants of copulatory behavior in rats.

Dewsbury¹

1975

Journal of Comparative and Physiological Psychology

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“…These animals are referred to as induced ovulators . Prairie voles ( Microtus ochrogas te r) and montane voles ( Micro tus montanus) are induced ovulators (Gray, Davis, Zerylnick § ; Richmond § Conaway, 1969).…”

Section: Variations In Copulatory Behavior and Reproductive Successmentioning

confidence: 99%

“…Some of the variability is also due to genetic differences between strains of laboratory rats. Several studies have shown there to be quantitative differences in the copulatory behavior of different strains of lr.bjratory rats (Dewsbury, 1975b; McLean, Dupeire $ Elder, 1972;Khalen, 1961). This variability within laboratory rats makes it difficult to assess possible species differences between roof rats and laboratory rats with regard to the quantitative measures of copulation.…”

mentioning

confidence: 99%

Copulatory behavior of Rattus rattus / by Daniel Quen Estep.

Estep¹

1975

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Strain differences in the mating behavior of Sprague-Dawley, Long-Evans, and Wistar male rats

Cited by 9 publications

References 7 publications

Choosing the Optimal Rat Stock as a Model for Research into Pharmacological Correction of Male Sexual Dysfunction

Choosing the Optimal Rat Stock as a Model for Research into Pharmacological Correction of Male Sexual Dysfunction

A diallel cross analysis of genetic determinants of copulatory behavior in rats.

Copulatory behavior of Rattus rattus / by Daniel Quen Estep.

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