Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide

Braley, Helen C.; Freeman, Mavis

doi:10.1016/0008-8749(71)90026-8

Cited by 44 publications

(28 citation statements)

References 15 publications

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“…Despite the almost monoclonal characteristics of the antibody response to SSS-III, the genetic mechanisms that govern responsiveness to this antigen of relatively simple structure appear to be quite complex. They include an X-linked dominant gene that determines responsiveness to SSS-III in a decisive manner (1), in addition to other factors, presumably autosomal genes, that influence the magnitude of the response produced by mice possessing the Xlinked gene (1,29). The following observations, derived from these and other studies (1, Tables I and II), best illustrate some of the quantitative effects which appear to be produced by the latter.…”

Section: Genetic Controlmentioning

confidence: 67%

Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Amsbaugh

Hansen

Prescott

et al. 1974

The Journal of Experimental Medicine

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Serum IgM immunoglobulin levels and antibody responses to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) were assessed for F1, F2, and backcross progeny derived from crosses between high responding BALB/cAnN (B) and low responding CBA/HN (C) mice. The results obtained confirmed our original hypothesis, namely, that a major component, present on the X chromosome, governs the ability to respond to SSS-III in a decisive manner. Although all low responding C mice had low IgM levels, both intermediate and high responders had high IgM levels of the same magnitude. Treatment with bacterial lipopolysaccharides (LPS) resulted in a significant increase in the IgM levels of low responding C mice. While the IgM levels attained were similar to those of high responding B mice, not given LPS, no antibody specific for LPS appeared to be produced. These findings suggest that C mice are unable to make an IgM antibody response to SSS-III and other polysaccharide antigens, despite the fact that they possess the capacity to synthesize normal amounts of IgM immunoglobulin.

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Section: Genetic Controlmentioning

confidence: 67%

Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Amsbaugh

Hansen

Prescott

et al. 1974

The Journal of Experimental Medicine

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“…The high versus low responder status to these antigens seems to be the effect of a single dominant gene and the high responsiveness is transferable by lymphocytes (2). The nature of the genetic control of X-chromosome-linked immune responsiveness is consistent with antigen specific regulation, because, e.g., the DBA/2 strain has a genetically high-immune response for poly(I)-poly(C) and a similar low immune response for denatured DNA and SIII, while the SJL/J strain gives a high response to denatured DNA, and a low one to poly(I)-poly(C) and SIII (1)(2)(3)(4)(5)(6)(7). In view of the above, and in analogy to the histocompatibility-2 linked immune response (Ir) genes, we investigated whether there are lymphocyte alloantigen loci associated with the X-chromosome-linked Ir (immune response) genes (8)(9)(10)(11).…”

mentioning

confidence: 61%

Lymphocytes alloantigens associated with X-chromosome-linked immune response genes.

Zeicher¹,

Mozes²,

Lonai³

1977

Proc. Natl. Acad. Sci. U.S.A.

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A new polymorphic alloantigen system controlled by loci on the X-chromosome has been identified by using antisera from F1 hybrid mice differing in their X-chromosome. These alloantigens are associated with the X-linked immune response genes controlling the immune response to the so-called "thymus independent antigens" such as type III pneumococcal polysaccharide, poly(I)poly(C), and denatured DNA. They also show association with the histocompatibility locus present on the X-chromosome. They were mainly detected on a not yet characterized thymus-derived lymphocyte subpopulation. A certain similarity with the major histocompatibility complex of the mouse supports the possibility of additional I-like regions besides the I region of the histocompatibility-2 complex.

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“…Genes of this type may also be responsible for the IgM situation recently described by And6 and Fachet (1978) in the response to oxazolone, or by Levine (1971) for IgE response to benzylpenicilloyl in SJL mice. Unfortunately, information is unavailable concerning the isotypes expressed in systems where a participation of non-CH and non-H-2-linked Ir genes has been determined (Mozes et al 1969, Braley et al 1971, Pisetsky et al 1978.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing evidence has accumulated that non-CH and,non-H-2-1inkedregulatory genes participate in the control of antibody homogeneity Braun 1974, 1975) or affinity (Kim and Siskind 1978) and in the control of the "overall magnitude" of the response (Braley et al 1971, Mozes et al 1969,/~sj6 et al 1977, And6 and Fachet 1977, Pisetsky et al 1978. In the present report, we investigate the possibility that these genes may, in fact, be involved in the control of the expression of different antibody classes.…”

Section: Introductionmentioning

confidence: 90%

Genetic control of igG2a production in the response to sheep erythrocytes

Séman¹,

Zilberfarb²,

Stanislawski

et al. 1978

Immunogenetics

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A low IgG2a response in B10 mice during the primary response to sheep red blood cells (SRBC) is described. Analysis of the response in B10 × BALB/c hybrid progenies and in congenic strains indicates that this low response is a dominant phenotype placed under the control of a single Mendelian gene or a group of closely linked genes. This gene(s) is neither linked to CH allotypes orH2 haplotypes, nor is it sex-linked. It can be considered as an isotype- and antigenspecific regulatory gene of the immune response.

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Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide

Cited by 44 publications

References 15 publications

Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Lymphocytes alloantigens associated with X-chromosome-linked immune response genes.

Genetic control of igG2a production in the response to sheep erythrocytes

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