Strain differences in the acquisition of nicotine-induced conditioned taste aversion

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

“…1997;Heishman and Henningfield 2000). Notably, aversion in humans (Lundahl et al 2000) and experimental animals (Fudala et al 1985;Risinger and Oaks 1995;Risinger and Brown 1996;Gommans et al 2000;Shoaib et al 2002;Pescatore et al 2005;Le Foll and Goldberg 2005) has been observed with relatively high doses of nicotine, in concurrence with our observation that high doses of nicotine enhance Dyn synthesis and release in the striatum.…”

“…The Dyn-κ opioid receptor system is known to mediate aversive behaviors (Mucha and Hertz 1985;Pfeifer et al 1986;Bals-Kubic et al 1993), and enhanced Dyn synthesis and release, as seen in our studies, could be, in part, responsible for the reported aversive effects of nicotine. Nicotine causes aversion in experimental animals (Fudala et al 1985;Risinger and Oaks 1995;Risinger and Brown 1996;Gommans et al 2000;Shoaib et al 2002;Pescatore et al 2005;Le Foll and Goldberg 2005) and humans exposed to nicotine for the first-time report negative subjective effects (Foulds at al. 1997;Heishman and Henningfield 2000).…”

“…Nicotine displays rewarding and aversive properties in rodents (Fudala et al 1985;Risinger and Oaks 1995;Risinger and Brown 1996;Gommans et al 2000;Shoaib et al 2002;Pescatore et al 2005;Le Foll and Goldberg 2005), and first-time nicotine users report positive and negative affective effects (Foulds et al 1997;Heishman and Henningfield 2000). While the ability of nicotine to release dopamine in the mesolimbic system has been linked with its rewarding properties (Di Chiara 2000), the neurotransmitter(s) involved with nicotine's aversion has not been established.…”

The effects of nicotine on ethanol-induced conditioned taste aversions in Long–Evans rats

“…Ethanol's effects within the taste aversion procedure are generally robust and produce dose-dependent aversions (Broadbent et al 2002;Cailhol and Mormede 2002;Chester et al 1998;Escarabajal et al 2003;Quertemont 2003;Risinger and Cunningham 1998;Roma et al 2006), while aversions induced by nicotine are generally weaker and often non-dose-dependent (Etscorn et al 1986(Etscorn et al , 1987Iwamoto and Williamson 1984;Kunin et al 2001;Mucha 1997;Pescatore et al 2005;Shoaib et al 2000).…”

CREB involvement in the regulation of striatal prodynorphin by nicotine

“…Similar to κ-agonists (Mucha and Hertz 1985;Pfeiffer et al 1986;Bals-Kubik et al 1989Todtenkopf et al 2004;Carlezon et al 2006;Muschamp et al 2011), elevated CREB activity in NAc produces depressive-like effects and signs of anhedonia and dysphoria (Carlezon et al 1998;Pliakas et al 2001;Muschamp et al 2011). Nicotine displays both rewarding and aversive properties in rodents (Fudala et al 1985;Rissinger and Oakes 1995;Gommans et al 2000;Shoaib et al 2002;Pescatore et al 2005), and first-time nicotine users report positive and negative affective effects (Foulds et al 1997;Heisman and Henningfiled 2000). Enhanced Dyn synthesis and release in NAc might contribute to the aversive and negative affective effects of acute nicotine.…”