Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress

Pothion, Stéphanie; Bizot, Jean-Charles; Trovero, Fabrice; Belzung, Catherine

doi:10.1016/j.bbr.2004.04.008

Cited by 355 publications

(254 citation statements)

References 33 publications

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“…Similarly to the effects of chronic mild stress (Pothion et al, 2004;Surget et al, 2008), aging was found to result in suppressed grooming behavior in a classical splash test model: 18-month-old mice exhibited significantly shorter duration of grooming behavior than 3-month-old animals (Fig. 4F).…”

Section: Reduced Grooming Of 18-month-old Mice In a Splash Testmentioning

confidence: 70%

“…Aging in rodents resulted in diminished place preference conditioned to a food (Rubinow et al, 2009), nicotine, cocaine, morphine and alcohol (Vastola et al, 2002;Campbell and Wood, 2000). It is also associated with lower novelty exploration (Vastola et al, 2002;Campbell and Wood, 2000) and decreased scores of grooming (Scimonelli et al, 1999;Shoji and Mizoguchi, 2011), which are considered to reflect a reduced self-rewarding activity (Pothion et al, 2004;Dubreucq et al, 2010;Gómez-Lázaro et al, 2011;Park et al, 2011). Together, these findings from animal studies parallel clinical features of elderly depression, which are predominantly related to hedonic deficits (Gallo et al, 1994(Gallo et al, , 1997.…”

Section: Introductionmentioning

confidence: 75%

“…This test was performed as described elsewhere (Pothion et al, 2004;Surget et al, 2008). A 10% sucrose solution was spread on the dorsal surface of a mouse coat, which because of its high viscosity induces lasting grooming behavior in mice.…”

Section: Splash Testmentioning

confidence: 99%

“…For example, anhedonia-like behavior defined by a decrease in sucrose intake and preference in chronically stressed C57BL/6N mice accompanies an increase in floating during forced swimming and immobility behavior in the modified tail suspension test (Strekalova et al, 2004;Strekalova and Steinbusch, 2010;Kanarik et al, 2011). These changes are often associated with a reduction in novelty exploration and grooming behavior in the splash test (Strekalova et al, 2004;Skrinskaia and Nikulina, 1994;Pothion et al, 2004). Antidepressant treatment counteracts the above-mentioned depressive-like traits in rodents (Porsolt and Papp, 1998;Willner, 2005;Strekalova et al, 2011;Yacoubi et al, 2011;Surget et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Our preliminary experiments demonstrated that depressive-like behaviors are accompanied by general locomotor and consumatory abnormalities in 25-but not 18-monthold C57BL6/N mice (Bolkunov et al, 2009). To determine whether 18-month-old animals display depressive features without generalized psychomotor deficits, they were compared to 3-month-old mice in an extended test battery for commonly used measures of anhedonia, behavioral despair, anxiety-like behavior, grooming, exploration and locomotion (Pothion et al, 2004;Surget et al, 2008;Strekalova, 2008;Strekalova and Steinbusch, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

Malatyńska

Steinbusch

Redkozubova

et al. 2012

Experimental Gerontology

103

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The prevalence of depression increases with aging. We hypothesized that like humans, old animals exhibit anhedonic-like behavior, along with signs of behavioral despair. In rodents, anhedonia, a reduced sensitivity to reward, which is listed as a core feature of major depression in the DSM-IVR, can be measured by a decrease in intake of and preference for sweet solutions. Here, sucrose intake, forced swimming, immobility in the modified tail suspension test, novelty exploration, grooming, anxiety and locomotor activity were compared in naïve 3-and 18-month-old male C57BL/6 mice. The absolute amounts and the ratio of consumed 1% sucrose solution to water intake was significantly smaller in 18-month-old mice than in 3-month-old mice. The consumption of 5%-sucrose solution requiring high levels of drinking effort, novelty exploration in two setups and grooming behavior in the splash test were reduced in older animals. Analysis of other behaviors suggested that the above-mentioned signs of anhedonic-like traits were unlikely to be attributable to the potential effect of aging on metabolic needs for water, taste perception, motor capabilities or the induction of essential anxiety and neophobia. A 4-week treatment with the antidepressant imipramine (7 mg/kg/day) or dimebon, a compound with suggested neuroprotective proneurogenic properties (1 mg/kg/day) restored sucrose intake and preference in 18-month-old mice. Meanwhile, young and old mice showed no differences in the parameters of behavioral despair evaluated in the forced swim and modified tail suspension tests. Thus, the behavioral profile of aged mice parallels that of humans with elderly depression, in whom the symptoms of hedonic deficits typically outweigh affective disturbances. The assessment of anhedonic-like traits with the sucrose preference test in 18-month-old mice will be useful in preclinical studies of elderly depression.

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Section: Reduced Grooming Of 18-month-old Mice In a Splash Testmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 75%

Section: Splash Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

Malatyńska

Steinbusch

Redkozubova

et al. 2012

Experimental Gerontology

103

View full text Add to dashboard Cite

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Models of Depression: Unpredictable Chronic Mild Stress in Mice

2013

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Major depression is a complex psychiatric disorder characterized by affective, cognitive, and physiological impairments that lead to maladaptive behavior. The high lifetime prevalence of this disabling condition, coupled with limitations in existing medications, make necessary the development of improved therapeutics. This requires animal models that allow investigation of key biological correlates of the disorder. Described in this unit is the unpredictable chronic mild stress mouse model that is used to screen for antidepressant drug candidates. Originally designed for rats, this model has been adapted for mice to capitalize on the advantages of this species as an experimental model, including inter-strain variability, which permits an exploration of the contribution of genetic background, the ability to create transgenic animals, and lower cost. Thus, by combining genetic features and socio-environmental chronic stressful events, the unpredictable, chronic mild stress model in mice can be used to study the etiological and developmental components of major depression, and to identify novel treatments for this condition.

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Depression‐Related Behavioral Tests

2012

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Overlapping characteristics between human depressive phenotypes and mouse behaviors has led to the creation of mouse models that aim to investigate the pathophysiology and treatment of unipolar depression. Behavioral tests in mice are used to assess and quantify the extent to which a mouse model displays a depression-like phenotype. The forced swim test and tail suspension test, sucrose preference test, and novelty suppressed feeding tests all aim to measure different components of depression. However, each one of these tests has different strengths and weaknesses in terms of predictive, face and construct validities. Furthermore, the responses to these tests vary greatly depending on strain of mouse. Depression-related behavioral tests are an extremely useful investigative tool in unearthing causes and predicting treatment outcomes in human depression, but as this review demonstrates, the comprehension of the finer details are extremely important in the design, analysis, and evaluation of such mouse studies. Curr. Protoc. Mouse Biol. 2:119-127 © 2012 by John Wiley & Sons, Inc.

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Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress

Cited by 355 publications

References 33 publications

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

Models of Depression: Unpredictable Chronic Mild Stress in Mice

Depression‐Related Behavioral Tests

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