Strain differences in muscarinic cholinergic receptor antagonism of fat intake and acquisition and expression of fat-conditioned flavor preferences in male BALB/c, C57BL/6 and SWR mice

Iskhakov, Ben; Dohnalova, Petra; Iskhakova, Julia; Mustac, Tatjana; Yuabov, Asnat; Macanian, Jason; Israel, Emanuel; Locurto, Nicole; Franz, Nicole; Fazilov, Gabriela; Shenouda, Merna; Bodnar, Richard J.

doi:10.1016/j.pbb.2019.172792

Cited by 2 publications

(2 citation statements)

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“…Scopolamine, a rodent-specific cholinergic receptor antagonist, reduced intralipid consumption and prevented the development of fat-condition flavor preferences in three strains of mice (inbred C57BL/6 and BALB/c, and SWR). These results suggest that cholinergic receptor signaling is essential for regulating fat intake and the development of fat taste preference ( 101 ).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, acetylcholine neurotransmitter function has been studied in the context of fat taste. Iskhakov et al ( 101 ) examined the effect of cholinergic inhibition on intralipid intake in mice. Scopolamine, a rodent-specific cholinergic receptor antagonist, reduced intralipid consumption and prevented the development of fat-condition flavor preferences in three strains of mice (inbred C57BL/6 and BALB/c, and SWR).…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of the biological mediators of fat taste and smell

Jaime-Lara

Brooks

Vizioli

et al. 2023

Physiological Reviews

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Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%