Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.

Yukawa, Kazunori; Kikutani, Hitoshi; Inomoto, Takeaki; Uehira, Masahiro; Bin, Sun Hui; Akagi, Kiwamu; Yamamura, Ken‐ichi; Kishimoto, Tadamitsu

doi:10.1084/jem.170.3.711

Cited by 44 publications

(15 citation statements)

References 46 publications

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“…6,7) We previously produced transgenic mice by introducing Eµ (immunoglobulin heavy chain enhancer)-myc gene into two inbred strains of mice, C57BL/6J (B6) and C3H/HeJ (C3H). 8) By analyses of these transgenic mice we found that most B6 transgenic mice developed B cell lymphomas while T cell lymphomas developed in most C3H transgenic mice. Furthermore, the average age of onset in inbred strains of mice is much earlier than in outbred strains.…”

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confidence: 91%

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Strain‐dependency of Chromosomal Abnormalities in Lymphomas Developed in Eμ‐myc Transgenic Mice

Akagi

Yamamura

2001

Japanese Journal of Cancer Research

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confidence: 91%

“…8,9) The C3H Eµ-myc 24 line was chosen because offspring were obtained only from this line. The F 1 hybrid Eµ-myc mice were obtained by crossing C3H/HeJ transgenic mice with either B6 or BALB/c mice (Clea Japan, Inc., Tokyo).…”

Section: Methodsmentioning

confidence: 99%

Strain‐dependency of Chromosomal Abnormalities in Lymphomas Developed in Eμ‐myc Transgenic Mice

Akagi

Yamamura

2001

Japanese Journal of Cancer Research

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“…In the mice injected subcutaneously with methylcolanthrene, the allelotype of aryl hydrocarbon hydroxylase locus determines whether the tumours are lymphomas or sarcomas at the injection site (Duran-Reynals, 1978). Eµ-myc transgene induce B-lineage lymphomas (Harris et al, 1988) in many mouse strains but in C3H, T-lymphomas occur predominantly (Yukawa et al, 1989), although the host gene responsible has not been identified. Similar genetic determination of T-lymphomas is also indicated in rats (Shisa and Hiai, 1985).…”

Section: Discussionmentioning

confidence: 99%

Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis

Shisa

Tanuma

et al. 1999

Br J Cancer

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Our recent studies have shown that types of lymphomas and leukaemias are determined by host genes in certain experimental models (Yamada et al, 1994a(Yamada et al, , 1994b. Propylnitrosourea (PNU)-induced T-lymphomas are one such example. F344 rats exhibit high susceptibility, whereas many other strains of rats develop predominantly erythro-or myeloid leukaemias (Shisa and Hiai, 1985;Shisa and Suzuki, 1991) We have assumed that a single dominant gene of F344 rats determines the susceptibility to T-lymphomas and that another independently segregating dominant gene determines the length of the latency period (Shisa and Hiai, 1985). Subsequent efforts to map such genes with crosses between F344 and LE rats, however, have met with great difficulty (Shisa et al, unpublished observation). The difficulty seems to arise partly from paucity of rat genetic marker at that time and partly because these traits are quantitative in nature and mutigenic, rather than a single gene inheritance.The recombinant inbred (RI) strains represent a set of stable inbred strains derived from F2 intercross between two parental inbred stains. The RI strains are extremely useful for the genetic analysis of complex traits (Taylor, 1978;Bailey, 1981). To analyse T-lymphoma susceptibility, we have established a new set of rat RI strains, LEXF, from matings between F344 and LE/Stm strains rats. The LEXF RI strains comprise 11 independent strains and 13 of their sublines. The strain distribution pattern (SDP) of LEXF has been extensively analysed (Shisa et al, 1997;Lu et al, 1998).In this paper, we report the PNU-induced carcinogenesis in the LEXF RI strains, and survey the host genes responsible for determination of the disease types and length of the latency period calculated using quantitative trait locus (QTL) analysis with the Map Manager QT software developed by Manly (1993). We found that numerous QTL with opposed functions are involved in determining the types of lymphomas and latency periods. To control type I and type II errors (Belknap et al, 1992(Belknap et al, , 1996, we further evaluated these putative loci in 137 backcross generation of (F344 × LE)F1 × LE rats. Significant linkage with T-lymphomagenesis was confirmed for three loci on chromosome 5, 7 and 10 and suggestive linkage, for a locus on chromosome 1. MATERIALS AND METHODS AnimalsThe LE/Stm rats were originally derived from a closed colony of Long-Evans rats at Ben May Laboratory, University of Chicago (Chicago, IL, USA) and maintained at Saitama Cancer Center Research Institute by brother-sister matings for > 50 generations. The F344 rats were derived from a pair of F344/DuCrj rats purchased from Charles River Japan, Inc. (Kanagawa, Japan) and thereafter maintained by brother-sister matings for > 23 generations. The LEXF was a set of 11 independent RI strains and 13 sublines (Shisa et al, 1997) In this study all LEXF RI strains except for LEXF 6B, a poor breeder, were used. These sublines were branched out at the 7th to 11th generations after an attempt to fix coat colour. ...

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“…For example, initogenic stimulation or chemically induced differentiation of certain cell lines results in changes in the levels of c-myc, c-myb, and c-fos proto-oncogenes (5,9,12,15,19,26,31). A constitutively high level of c-myc gene is detected in Burkitt's lymphoma cells (4) and development of B and T lymphoma is observed in Ey-mrc transgenic mice (37).…”

Section: Discussionmentioning

confidence: 99%

Elevated Expression of Proto‐Oncogenes during Interleukin‐5‐Induced Growth and Differentiation of Murine B Lineage Cells

Migita

Yamaguchi²,

Katoh³

et al. 1990

Microbiology and Immunology

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Interleukin 5 (IL-5), a lymphokine produced by helper T cells, is involved in the regulation of growth and differentiation of B cells and other hematopoietic cells. To elucidate IL-5-mediated intracellular mechanisms, we have established. IL-5-dependent and -independent murine early B cell lines, J6 and MJ88-1, respectively, and examined the effect of IL-5 on the expression of proto-oncogenes during proliferation. Two-to 3.5-fold increases in the levels of c-myb, c-myc, c-fos, and mRNA were observed in J6 cells, compared with those in MJ88-1 cells. Further, a role of IL-5 in the proto-oncogene expression during differentiation was examined by using thymidine-treated murine B-cell chronic leukemia BCL1-B20 cells with growth arrest.After 4-day culture, the amount of IgM secreted from BCL1-B20 cells was augmented 4-6 fold in the presence of IL-5.Although expression of c-myb, c-fos, and c-fms mRNA did not change, only c-myc mRNA expression was elevated within 30 min of stimulation with IL-5 and reached a maximal level by 1 hr. Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA.These findings suggest that the IL-5 signal may be associated with the up-regulation of c-myc expression.Recently, proto-oncogenes have been in the forefront of potential factors involved in proliferation and differentiation of hematopoietic progenitor cells. The increased expression of c-myc, c-fos, and c-myb proto-oncogenes has been shown in the growth factor-induced proliferation of various cells including normal human T, B cells and mouse fibroblasts (9,15,26). In contrast, decreased expression of c-myc, c-myb proto-oncogenes was observed during the differentiation of human cell lines, HL-60, and U-937 into granulocytes and monocytes, respectively (5, 31).Interleukin-5 (IL-5) is a T cell-derived soluble factor that enhances the proliferation and differentiation of B cells as well as eosinophils (21,27,35). Cloning of cDNA for murine IL-5 and production of monoclonal antibodies against IL-5 937

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Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.

Cited by 44 publications

References 46 publications

Strain‐dependency of Chromosomal Abnormalities in Lymphomas Developed in Eμ‐myc Transgenic Mice

Strain‐dependency of Chromosomal Abnormalities in Lymphomas Developed in Eμ‐myc Transgenic Mice

Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis

Elevated Expression of Proto‐Oncogenes during Interleukin‐5‐Induced Growth and Differentiation of Murine B Lineage Cells

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