Strain-dependence of age-related cochlear hearing loss in wild and domesticated Mongolian gerbils

Influence of Ketamine–Xylazine Anaesthesia on Cubic and Quadratic High-Frequency Distortion-Product Otoacoustic Emissions

“…: Influence of Ketamine-Xylazine Anaesthesia on High-Frequency Otoacoustic Emissionsdependent decrease of optimum ration is also found in certain other mammals (e.g. Eckrich et al 2008). The decrease of the optimum ratio with f2 was more pronounced for QDTs than for CDTs, both in the anaesthetised and in the awake bats.…”

“…Kössl 1992, Kössl et al 1999Kössl and Vater 2000;Wittekindt et al 2005;Macias et al 2006) and also in other mammalian species (e.g. Drexl et al 2003;Eckrich et al 2008). In Figure 2, two example growth functions are shown that illustrate the advantage of this procedure.…”

“…For all average curves, the data were given with error bars of one standard deviation. For more detailed description of the experimental procedures, see Eckrich et al (2008) and Althen et al (2012).…”

The Mongolian Gerbil as a Model for the Analysis of Peripheral and Central Age-Dependent Hearing Loss

“…They can be used to determine the sensitivity of the cochlea and to construct audiograms (Janssen et al, 2006). Eckrich et al (2008) measured DPOAE audiograms of "laboratory" gerbils and gerbils that had been caught in the wild and bred for 6-7 generations in captivity. While thresholds of "wild" gerbils remained stable across age, thresholds of 15-28 month old, domesticated gerbils were increased at 2 kHz (6 dB), between 8 and 20 kHz (6-11 dB) and above 44 kHz (6-12 dB), when compared to the thresholds of 3 and 6 month old, domesticated gerbils.…”

“…For the most basal test frequencies above 50 kHz, threshold elevation of more than 6 dB was present in the 9 and 12 month old, domesticated gerbils. Eckrich et al (2008) suggested that elevated DPOAE thresholds in the older gerbils may have been caused by a loss of the endocochlear potential and/or a loss of outer hair cells.…”