Gold nanoparticles (AuNPs) were anchored on alkynyl carbamate-functionalized support materials having the suitable features for application as catalysts in continuous-flow packed bed reactors. The functionalization step was carried out by grafting with the di-functional organosilane [3-(2-propynylcarbamate)propyl]triethoxysilane (PPTEOS) three commercial micrometer-sized oxide supports, i.e. silica, alumina, and titania. The alkynyl-carbamate moieties were capable to straightforwardly reduce the gold precursor HAuCl4 yielding the supported AuNPs systems Au/SiO2@Yne, Au/Al2O3@Yne, and Au/TiO2@Yne. A comparison among the three materials revealed that silica allowed the highest organic functionalization (12 wt%) as well as the highest gold loading (3.7 wt%). Moreover, TEM investigation showed only for Au/SiO2@Yne the presence of homogeneously distributed, spherically shaped AuNPs (av. diameter 15 nm). Au/SiO2@Yne is an efficient catalyst, both in batch and flow conditions, in the oxidation of a large variety of alcohols, using H2O2 as oxidizing agent, at a temperature of 90 °C. Furthermore, under flow conditions, the catalyst worked for over 50 h without any significant decrease in the catalytic activity. The catalytic activity of the three catalysts was evaluated and compared in the oxidation of 1-phenylethanol as a model substrate. We found that the flow approach plays a strategic role in preserving the physical and chemical integrity of the solid catalysts during its use, with remarkable consequences for the reaction conversion (from 2% in batch to 80 % in flow) in the case of Au/TiO2@Yne