Many soil and weather variables can affect the economical optimum nitrogen (N) rate (EONR) for maize. We classified 54 potential factors as dynamic (change rapidly over time, e.g. soil water) and static (change slowly over time, e.g. soil organic matter) and explored their relative importance on EONR and yield prediction by analyzing a dataset with 51 N trials from Central-West region of Argentina. Across trials, the average EONR was 113 ± 83 kg N ha −1 and the average optimum yield was 12.3 ± 2.2 Mg ha −1 , which is roughly 50% higher than the current N rates used and yields obtained by maize producers in that region. Dynamic factors alone explained 50% of the variability in the EONR whereas static factors explained only 20%. Best EONR predictions resulted by combining one static variable (soil depth) together with four dynamic variables (number of days with precipitation>20 mm, residue amount, soil nitrate at planting, and heat stress around silking). The resulting EONR model had a mean absolute error of 39 kg N ha −1 and an adjusted R 2 of 0.61. Interestingly, the yield of the previous crop was not an important factor explaining EONR variability. Regression models for yield at optimum and at zero N fertilization